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. 2021 Sep 7;8:730553. doi: 10.3389/fcvm.2021.730553

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Copyright © 2021 Hatanaka, Ito, Madokoro, Kamikokuryo, Niiyama, Yamada, Maruyama and Kakihana.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circulating syndecan-1 is associated with disseminated intravascular coagulation (DIC). (A) Serum syndecan-1 levels in non-DIC and DIC patients (n = 34 and 64 on Day 1 and n = 33 and 62 on Day 3, respectively). The lines in the graph indicate the medians with interquartile ranges. The differences between non-DIC and DIC patients were analyzed using the Mann–Whitney U-test. *P < 0.05. **P < 0.01. (B) Relationship between serum syndecan-1 on Day 1 and DIC score on Day 1. Spearman's rank correlation test indicated a weak but significant correlation (Spearman's rho = 0.33, P < 0.01).