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. 2021 Sep 7;8:730553. doi: 10.3389/fcvm.2021.730553

Figure 5.

Figure 5

Circulating syndecan-1 is associated with persistent thrombocytopenia. (A) Relationships between serum syndecan-1 on Day 1 and individual components of the DIC score on Days 1, 3, 5, and 7 in the subpopulation who stayed in the ICU until at least Day 7 (n = 43). The intensities of the correlation are color-coded according to the Spearman's rho values, with red and blue colors indicating positive and negative correlations, respectively. PLT, platelets; FDP, fibrin(ogen) degradation products; PT, prothrombin time; SIRS, systemic inflammatory response syndrome score; FIB, fibrinogen. *P < 0.05. **P < 0.01. (B) Correlations between serum syndecan-1 on Day 1 and platelet counts on Days 1, 3, 5, and 7 in the whole population with sepsis (n = 99 on Day 1; n = 97 on Day 3; n = 69 on Day 5; n = 43 on Day 7). (C) Platelet counts on Days 1, 3, 4, 5, 6, and 7 in patients with low serum syndecan-1 (<21.4 ng/mL, n = 67) and high serum syndecan-1 (≥21.4 ng/mL, n = 32). The bold lines indicate the median values and the filled-in areas indicate interquartile ranges. The optimal cut-off value (21.4 ng/mL) was determined by ROC analysis (Supplementary Figure 2).