Table 1.
Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination.
| Author, years | Age | Sex | Comorbidity | Type of vaccines | Dose | Days of onset after vaccination | Days of total course | Clinical presentation | Histopathology | Treatment |
|---|---|---|---|---|---|---|---|---|---|---|
| Akdas et al., (1) | 45 | F | None | Inactivated CoronaVac | 1st | 4 | 7 | - Multiple round, salmon-colored plaques on trunk and extremities, resembling a Christmas tree distribution | - Focal parakeratosis - Exocytosis of lymphocytes - Spongiosis - Extravasated red blood cells in the dermis | - Mid-potency topical corticosteroid cream |
| Adya et al., (2) | 21 | M | None | ChAdOx1 nCoV- 19, Covishield™ | 1st | 4 | N/A | - Papulovesicular eruptions on trunk and extremities along skin cleavage line - A targetoid aspect with central hemorrhagic crust on some lesions |
- Spongiosis - Perivascular lymphocytic infiltrate - Extravasated red blood cells in the dermis | N/A |
| Abdullah et al., (3) | 40 | M | None | BNT162b2 mRNA | 2nd | 7 | 21 | - Disseminated erythematous scaly patches on trunk and extremities - Herald patch on back |
N/A | - Triamcinolone acetonide cream 0.1% |
| Cyrenne et al., (4) | 20s | F | Alopecia areata | BNT162b2 mRNA | 1st and 2nd | 2 | 14 | - Large, red-to-tan, scaly plaques at the inoculation site followed by eruptions on the trunk | - Parakeratosis - Minimal acanthosis and spongiosis - Interface changes - Scattered dyskeratotic keratinocytes | - Topical corticosteroids |
| 40s | M | None | BNT162b2 mRNA | 2nd | 21 | 21 | - Pruritic, red-to-tan, small oval plaques with peripheral scales on the trunk and proximal extremities - Herald patch on left axilla |
N/A | - Doxycycline - Bilastine |
|
| Present case | 52 | F | Recurrent glioblastoma | ChAdOx1 nCoV-19, Oxford/AstraZeneca | 1st | 14 | 7 | - Multiple erythematous to dusky oval patches and plaques on the trunk and upper legs | - Epidermal focal spongiosis - Interface changes and necrotic keratinocytes - Superficial lymphocytic infiltrate | - Triamcinolone acetonide cream 0.1% |
F, female; M, male; N/A, not available.