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. 2021 Sep 7;8:752443. doi: 10.3389/fmed.2021.752443

Table 1.

Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination.

Author, years Age Sex Comorbidity Type of vaccines Dose Days of onset after vaccination Days of total course Clinical presentation Histopathology Treatment
Akdas et al., (1) 45 F None Inactivated CoronaVac 1st 4 7 - Multiple round, salmon-colored plaques on trunk and extremities, resembling a Christmas tree distribution - Focal parakeratosis - Exocytosis of lymphocytes - Spongiosis - Extravasated red blood cells in the dermis - Mid-potency topical corticosteroid cream
Adya et al., (2) 21 M None ChAdOx1 nCoV- 19, Covishield™ 1st 4 N/A - Papulovesicular eruptions on trunk and extremities along skin cleavage line
- A targetoid aspect with central hemorrhagic crust on some lesions
- Spongiosis - Perivascular lymphocytic infiltrate - Extravasated red blood cells in the dermis N/A
Abdullah et al., (3) 40 M None BNT162b2 mRNA 2nd 7 21 - Disseminated erythematous scaly patches on trunk and extremities
- Herald patch on back
N/A - Triamcinolone acetonide cream 0.1%
Cyrenne et al., (4) 20s F Alopecia areata BNT162b2 mRNA 1st and 2nd 2 14 - Large, red-to-tan, scaly plaques at the inoculation site followed by eruptions on the trunk - Parakeratosis - Minimal acanthosis and spongiosis - Interface changes - Scattered dyskeratotic keratinocytes - Topical corticosteroids
40s M None BNT162b2 mRNA 2nd 21 21 - Pruritic, red-to-tan, small oval plaques with peripheral scales on the trunk and proximal extremities
- Herald patch on left axilla
N/A - Doxycycline
- Bilastine
Present case 52 F Recurrent glioblastoma ChAdOx1 nCoV-19, Oxford/AstraZeneca 1st 14 7 - Multiple erythematous to dusky oval patches and plaques on the trunk and upper legs - Epidermal focal spongiosis - Interface changes and necrotic keratinocytes - Superficial lymphocytic infiltrate - Triamcinolone acetonide cream 0.1%

F, female; M, male; N/A, not available.