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. 2021 Sep 7;8:742903. doi: 10.3389/fmolb.2021.742903

FIGURE 1.

FIGURE 1

PLEV and EYYV docking to the FGF14:Nav1.6 complex (modified Singh et al., 2020. Physiol Rep. PMID: 32671946). (A,B) Representation of PLEV (pink-orange) and EYYV (yellow) peptide fragments docked into the FGF14 chain of the FGF14:Nav1.6 C-terminal tail homology model. FGF14 has depicted as sky blue ribbons. Key interaction residues are highlighted as stick representations. H-bonds are shown as purple dotted lines, salt bridges are shown as red dotted lines. Residues shown in the map are within 4 Å cut-off. (C) Overlay of PLEV (pink-orange) and EYYV (yellow) docked poses and FGF14. Nav1.6 C-terminal tail complex homology model. The FGF14 chain is depicted as sky blue ribbons and the Nav1.6 C-terminal tail is highlighted as gray ribbons. The overlay analysis demonstrated the peptides bound with FGF14 to the different locations at the FGF14:Nav1.6 C-tail protein-protein interaction (PPI) interface. (D) Surface representation of PLEV (pink-orange) and EYYV (yellow) peptide fragments docked pose overlay with FGF14 (cyan). (E) table representing the Key interacting residues of FGF14:Nav1.6 C-terminal tail PPI with PLEV and EYYV.