TABLE 1.
Nav1.6 currents in the presence of FGF14 and tetrapeptides PLEV, EYYV.
| Condition | Peak density | Activation | Kact | Steady-state inactivation | Kinact | Tau (τ) |
|---|---|---|---|---|---|---|
| pA/pF | mV | mV | mV | mV | Ms | |
| GFP DMSO | −59.63 ± 5.33 (14) | −27.98 ± 1.48 (15) | 5.23 ± 0.55 (12) | −60.93 ± 1.3 (13) | 5.88 ± 0.59 (13) | 1.06 ± 0.06 (12) |
| GFP PLEV | −64.66 ± 9.1 (11) | −28.01 ± 1.67 (11) | 3.97 ± 0.57 (11) | −66.9 ± 3.25 (10) | 5.90 ± 0.87 (10) | 1.48 ± 0.25 (11) |
| GFP EYYV | −57.09 ± 4.66 (14) | −24.56 ± 1.20 (11) | 4.37 ± 0.40 (11) | −64.93 ± 2.31 (9) | 6.57 ± 0.37 (9) | 1.14 ± 0.06 (13) |
| FGF14-GFP DMSO | −20.58 ± 3.03 (11)a | −24.21 ± 1.02 (12)b | 6.66 ± 0.84 (12) | −56.67 ± 0.69 (14)c | 6.52 ± 0.74 (14) | 1.72 ± 0.24 (14)d |
| FGF14-GFP PLEV | −39.51 ± 5.54 (8)e | −24.35 ± 1.10 (8) | 4.55 ± 0.39 (8) | −67.66 ± 5.85 (7)f | 7.89 ± 0.90 (7) | 1.54 ± 0.14 (8) |
| FGF14-GFP EYYV | −18.1 ± 3.92 (10) | −22.11 ± 1.49 (10) | 5.97 ± 0.69 (10) | −66.59 ± 4.16 (9)g | 6.91 ± 0.65 (9) | 1.66 ± 0.12 (10) |
Data are mean ± SEM. ns, non-significant.
a
p < 0.0001, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to GFP DMSO.
b
p = 0.0428, Student’s t-test compared to GFP DMSO.
c
p = 0.007, Student’s t-test compared to GFP DMSO.
d
p = 0.0337, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to GFP DMSO.
e
p = 0.0258, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to GFP DMSO.
f
p = 0.0497, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to FGF14-GFP DMSO.
g
p = 0.0084, Student’s t-test compared to FGF14-GFP DMSO.