TABLE 3.
Nav1.6 channel LTI in the presence of FGF14 and tetrapeptides PLEV, EYYV.
| Condition | LTI (% Maximal Na+ current) | ||
|---|---|---|---|
| 2nd Pulse | 3rd Pulse | 4th Pulse | |
| GFP DMSO | 95.12 ± 1.66 (11) | 94.82 ± 0.83 (11) | 94.41 ± 1.05 (11) |
| GFP PLEV | 92.1 ± 2.22 (11) | 90.48 ± 2.03 (11) | 88.55 ± 1.87 (11) |
| GFP EYYV | 91.69 ± 2.11 (11) | 91.53 ± 2.01 (11) | 91.48 ± 1.93 (11) |
| FGF14-GFP DMSO | 99.77 ± 4.01 (11) | 101.4 ± 4.74 (11) | 104.9 ± 6.39 (11) |
| FGF14-GFP PLEV | 76.06 ± 8.44 (7)a | 73.56 ± 5.92 (7)b | 74.69 ± 8.05 (7)c |
| FGF14-GFP EYYV | 94.24 ± 4.33 (9) | 101.4 ± 8.29 (9) | 101.5 ± 6.16 (9) |
Data are mean ± SEM. ns, non-significant.
a
p = 0.0125, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to FGF14-GFP DMSO.
b
p = 0.0009, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to FGF14-GFP DMSO.
c
p = 0.0002, one-way ANOVA post hoc Tukey’s multiple comparisons test compared to FGF14-GFP DMSO.