TABLE 3.
Liver function indexes in CUMS and healthy rats administration with PBR (Mean ± SD, n = 8).
| Group | ALP | ALT | AST | TBIL |
|---|---|---|---|---|
| C1 | 226.5 ± 36.7##** | 51.8 ± 6.3** | 129.3 ± 8.6** | 11.1 ± 2.6 |
| C2 | 196.6 ± 39.7 | 59.1 ± 21.6* | 121.5 ± 21.1#*** | 7.3 ± 1.0# |
| C3 | 193.9 ± 28.4 | 64.1 ± 37.9 | 120.6 ± 10.2#** | 5.5 ± 2.7# |
| C4 | 176.8 ± 38.6 | 62.0 ± 9.3 | 118.3 ± 26.8#*** | 6.7 ± 2.9# |
| C5 | 229.5 ± 45.1 | 59.5 ± 13.4 | 137.2 ± 30.5* | 7.7 ± 1.5# |
| C6 | 267.8 ± 46.36##** | 67.1 ± 11.4 | 154.3 ± 18.6 | 9.2 ± 3.3 |
| C7 | 251.6 ± 50.3###*** | 72.8 ± 14.9 | 141.1 ± 32.7* | 7.7 ± 1.5# |
| Z1 | 189.9 ± 28.6 | 64.2 ± 8.5 | 141.7 ± 17.6 | 9.6 ± 1.9 |
| Z2 | 196.2 ± 28.6 | 66.9 ± 11.7 | 149.6 ± 15.5 | 10.7 ± 2.1* |
| Z3 | 235.3 ± 65.2## | 69.5 ± 11.4 | 161.7 ± 29.3 | 13.3 ± 5.2* |
| Z4 | 186.9 ± 22.7 | 84.7 ± 20.6 | 152.6 ± 22.0 | 10.3 ± 4.3* |
| Z5 | 200.7 ± 37.0## | 87.6 ± 14.1 | 179.6 ± 25.2 | 10.0 ± 3.3* |
| Z6 | 240.2 ± 55.1## | 69.3 ± 12.1 | 123.5 ± 28.3## | 9.0 ± 4.0* |
| Z7 | 251.6 ± 50.3### | 68.6 ± 19.4 | 148.9 ± 35.6 | 6.8 ± 1.2# |
| CM | 169.9 ± 24.4 | 78.8 ± 26.2 | 172.8 ± 44.6 | 8.7 ± 3.5# |
| K | 173.4 ± 19.4 | 64.0 ± 17.0 | 156.8 ± 44.5 | 10.8 ± 2.3* |
Note: [CM] CUMS rats, [K] control rats, [C1] ∼ [C7] CUMS rats given PBR (7 different dosages), [Z1] ∼ [Z7] control rats administered PBR, and [CY] CUMS rats administered venlafaxine hydrochloride. #, compared with the K group (#p < 0.05, ##p < 0.01, ###p < 0.001); *, compared with the CM group (*p < 0.05, **p < 0.01, ***p < 0.001).