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. 2021 Sep 7;8:713312. doi: 10.3389/fmed.2021.713312

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Copyright © 2021 Zillikens, Kasprick, Osterloh, Gross, Radziewitz, Hass, Hartmann, Behnen-Härer, Ernst, Boch, Vidarsson, Visser, Laskay, Yu, Petersen, Ludwig and Bieber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IC-induced spreading of PMNs mainly depends on PI3Kδ. Freshly isolated human blood PMNs were activated with immobilized ICs in the presence of either one of the PI3K isoform-selective inhibitors. (A) Microscopic appearance of PMNs 2 h after IC-stimulation. IC-stimulated PMNs show clear spreading on surface (arrows). The highest concentration of all inhibitors (1 μM) reduced the adhesion of PMNs. (B) Spreading was monitored live for 2 h and the area under curve (AUC) was analyzed. Data are shown as Tukey's box-and-whisker plots. n = 4. ANOVA on ranks (Kruskal-Wallis) was applied followed by a Bonferroni t-test for multiple comparisons. Data were normalized to IC-stimulated cells. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.