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. 2021 Sep 7;8:713312. doi: 10.3389/fmed.2021.713312

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Copyright © 2021 Zillikens, Kasprick, Osterloh, Gross, Radziewitz, Hass, Hartmann, Behnen-Härer, Ernst, Boch, Vidarsson, Visser, Laskay, Yu, Petersen, Ludwig and Bieber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune complex (IC)-induced reactive oxygen species (ROS) release from PMNs depends on different PI3K isoforms. Human PMNs were activated with immobilized ICs in the presence of either one of the PI3K isoform-selective inhibitors. Release of ROS was tracked for 2 h and the area under curve (AUC) was calculated. Data were normalized to positive control (IC-stimulated PMNs with solvent). Data are shown as Tukey's box-and-whisker plots. n = 6. ANOVA on ranks (Kruskal-Wallis) was applied followed by a Bonferroni t-test for multiple comparisons. Data were normalized to stimulated cells. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.