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. 2021 Sep 12;2021:6610529. doi: 10.1155/2021/6610529

Table 1.

KEGG pathway analysis of 5115 mtEPs revealed four statistically significant lipid metabolism pathway alterations in ovarian cancer.

Lipid metabolism pathways Accession Description Gene name Coverage Unique peptides Peptides PSMs MW (kDa) Calc. pI Average tumor/control t-test p value
Fatty acid degradation pathway E7ERD7 Long-chain fatty acid-CoA ligase 6 OS=Homo sapiens GN=ACSL6 PE=1 SV=1—[E7ERD7_HUMAN] ACSL6 8.27 3 5 7 75.20 7.42 1.38 6.22E − 03
B2RAQ8 cDNA, FLJ95058, highly similar to Homo sapiens carnitine palmitoyltransferase 1A (liver) (CPT1A), nuclear gene encoding mitochondrial protein, mRNA OS=Homo sapiens PE=2 SV=1—[B2RAQ8_HUMAN] CPT1A 34.41 22 22 47 88.28 8.59 1.41 9.89E − 03
P23786 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens GN=CPT2 PE=1 SV=2—[CPT2_HUMAN] CPT2 42.40 5 24 77 73.73 8.18 2.05 1.99E − 02
A0A024R8L7 Acyl-coenzyme A oxidase OS=Homo sapiens GN=ACOX1 PE=3 SV=1—[A0A024R8L7_HUMAN] ACOX1 29.85 14 14 23 74.64 7.62 1.53 3.40E − 02
D4QEZ8 Short-chain acyl-CoA dehydrogenase OS=Homo sapiens GN=ACADS PE=2 SV=1—[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43E − 06
P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1—[ACDSB_HUMAN] ACADSB 25.93 8 8 15 47.46 6.99 1.29 1.06E − 02
Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3—[ECHP_HUMAN] EHHADH 33.47 22 22 34 79.44 9.14 1.62 2.25E − 03
P30084 Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens GN=ECHS1 PE=1 SV=4—[ECHM_HUMAN] ECHS1 75.86 19 19 156 31.37 8.07 1.52 3.56E − 03
Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3—[ECHP_HUMAN] EHHADH 33.47 22 22 34 79.44 9.14 1.62 2.25E − 03
Fatty acid metabolism pathway Q9P035 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens GN=HACD3 PE=1 SV=2—[HACD3_HUMAN] HACD3 22.93 7 7 26 43.13 8.94 1.06 6.65E − 2
Q5VWC8 Very long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 OS=Homo sapiens GN=HACD4 PE=1 SV=1—[HACD4_HUMAN] HACD4 4.31 2 2 3 27.50 8.57 1.26 1.74E − 02
A0A0A0MTI6 Elongation of very long-chain fatty acid protein OS=Homo sapiens GN=ELOVL5 PE=1 SV=1—[A0A0A0MTI6_HUMAN] ELOVL5 3.05 1 1 2 30.72 7.52 1.37 1.94E − 03
P09110 3-Ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens GN=ACAA1 PE=1 SV=2—[THIK_HUMAN] ACAA1 46.23 4 14 50 44.26 8.44 2.70 1.00E − 02
D4QEZ8 Short-chain acyl-CoA dehydrogenase OS=Homo sapiens GN=ACADS PE=2 SV=1—[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43E − 06
P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1—[ACDSB_HUMAN] ACDSB 25.93 8 8 15 47.46 6.99 1.29 1.06E − 02
A0A024R8L7 Acyl-coenzyme A oxidase OS=Homo sapiens GN=ACOX1 PE=3 SV=1—[A0A024R8L7_HUMAN] ACOX1 29.85 14 14 23 74.64 7.62 1.53 3.40E − 02
E7ERD7 Long-chain fatty acid-CoA ligase 6 OS=Homo sapiens GN=ACSL6 PE=1 SV=1—[E7ERD7_HUMAN] E7ERD7 8.27 3 5 7 75.20 7.41 1.38 6.22E − 03
B2RAQ8 cDNA, FLJ95058, highly similar to Homo sapiens carnitine palmitoyltransferase 1A (liver) (CPT1A), nuclear gene encoding mitochondrial protein, mRNA OS=Homo sapiens PE=2 SV=1—[B2RAQ8_HUMAN] CPT1A 34.41 22 22 47 88.28 8.59 1.41 9.89E − 03
P23786 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens GN=CPT2 PE=1 SV=2—[CPT2_HUMAN] CPT2 42.40 5 24 77 73.73 8.18 2.05 1.99E − 02
Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3—[ECHP_HUMAN] EHHADH 33.47 22 22 34 79.44 9.14 1.62 2.25E − 03
P30084 Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens GN=ECHS1 PE=1 SV=4—[ECHM_HUMAN] ECHM 75.86 19 19 156 31.37 8.07 1.52 3.56E − 03
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3—[HCDH_HUMAN] HCDH 64.01 16 16 69 34.27 8.85 1.34 2.11E − 02
Q8N8R3 Mitochondrial basic amino acid transporter OS=Homo sapiens GN=SLC25A29 PE=1 SV=2—[MCATL_HUMAN] MCATL 20.13 6 6 7 32.04 8.75 1.07 4.30E − 02
Q9BY49 Peroxisomal trans-2-enoyl-CoA reductase OS=Homo sapiens GN=PECR PE=1 SV=2—[PECR_HUMAN] PECR 26.40 7 7 10 32.52 8.81 1.57 4.14E − 04
Q86SK9 Stearoyl-CoA desaturase 5 OS=Homo sapiens GN=SCD5 PE=1 SV=2—[SCD5_HUMAN] SCD5 9.70 2 2 4 37.59 9.61 0.77 1.05E − 02
Butanoate metabolism pathway D4QEZ8 Short-chain acyl-CoA dehydrogenase OS=Homo sapiens GN=ACADS PE=2 SV=1—[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43E − 06
Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3—[ECHP_HUMAN] EHHADH 33.47 22 22 34 79.44 9.14 1.62 2.25E − 03
P30084 Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens GN=ECHS1 PE=1 SV=4—[ECHM_HUMAN] ECHS1 75.86 19 19 156 31.37 8.07 1.52 3.56E − 03
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3—[HCDH_HUMAN] HADH 64.01 16 16 69 34.27 8.85 1.34 2.11E − 02
Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3—[ECHP_HUMAN] EHHADH 33.47 22 22 34 79.44 9.14 1.62 2.25E − 03
Q02338 D-Beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3—[BDH_HUMAN] BDH1 41.98 11 11 23 38.13 8.95 1.54 2.99E − 03
Q9BUT1 3-Hydroxybutyrate dehydrogenase type 2 OS=Homo sapiens GN=BDH2 PE=1 SV=2—[BDH2_HUMAN] BDH2 17.14 4 4 6 26.71 7.65 0.51 1.81E − 04
Q86V21 Acetoacetyl-CoA synthetase OS=Homo sapiens GN=AACS PE=1 SV=1—[AACS_HUMAN] AACS 2.68 2 2 2 75.10 6.24 1.35 5.30E − 04
P54868 Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Homo sapiens GN=HMGCS2 PE=1 SV=1—[HMCS2_HUMAN] HMGCS2 12.80 7 7 11 56.60 8.16 2.17 2.10E − 03
B1AK13 3-Hydroxymethyl-3-methylglutaryl-coenzyme A lyase (hydroxymethylglutaricaciduria), isoform CRA_b OS=Homo sapiens GN=HMGCL PE=2 SV=1—[B1AK13_HUMAN] HMGCL 53.00 13 14 49 31.71 7.61 1.33 2.91E − 03
Propanoate metabolism pathway Q7Z5G3 Acetyl-coenzyme A synthetase OS=Homo sapiens GN=ACSS1 PE=2 SV=1—[Q7Z5G3_HUMAN] ACSS1 17.32 10 10 11 74.61 7.23 0.82 1.17E − 02
A0A0B4J1R2 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Homo sapiens GN=ACSS3 PE=1 SV=1—[A0A0B4J1R2_HUMAN] ACSS3 42.48 23 23 62 74.54 8.63 0.83 8.45E − 04
Q6NVY1 3-Hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens GN=HIBCH PE=1 SV=2—[HIBCH_HUMAN] HIBCH 34.46 14 14 29 43.45 8.19 1.58 2.50E − 03
Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3—[ECHP_HUMAN] EHHADH 33.47 22 22 34 79.44 9.14 1.62 2.25E − 03
P30084 Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens GN=ECHS1 PE=1 SV=4—[ECHM_HUMAN] ECHS1 75.86 19 19 156 31.37 8.07 1.52 3.56E − 03
Q9NTX5 Ethylmalonyl-CoA decarboxylase OS=Homo sapiens GN=ECHDC1 PE=1 SV=2—[ECHD1_HUMAN] ECHDC1 9.45 3 3 10 33.68 8.21 1.69 3.67E − 03
Q96I99 Succinate-CoA ligase (GDP-forming) subunit beta, mitochondrial OS=Homo sapiens GN=SUCLG2 PE=1 SV=2—[SUCB2_HUMAN] SUCLG2 44.91 19 20 115 46.48 6.39 1.71 8.17E − 04
Q96I99 Succinate-CoA ligase (GDP-forming) subunit beta, mitochondrial OS=Homo sapiens GN=SUCLG2 PE=1 SV=2—[SUCB2_HUMAN] SUCLG2 44.91 19 20 115 46.48 6.39 1.71 8.17E − 04
Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens GN=MCEE PE=1 SV=1—[MCEE_HUMAN] MCEE 38.07 5 5 8 18.74 9.09 1.22 4.87E − 02