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. 2021 Sep 20;10(9):e1338. doi: 10.1002/cti2.1338

Figure 6.

Figure 6

Se supplementation attenuates ROS to suppress RANKL expression in activated CD4+ T cells. (a, b) Representative FASC plots and statistics showing the frequencies of IL‐17 (a) and RANKL (b) and in WT and Tcf7‐KO with or without Se‐Met for 72 h. (c, d) RANKL (c) and IL‐17 (d) expression on CD4+ T cells increased with different doses of TCR stimulation. (e) The levels of ROS in cultured CD4+ T cells with or without Se‐Met. (f, g) Representative FASC plots and statistics showing the frequencies of RANKL (f) and IL‐17 (g) under Th17 cell‐induction conditions, with or without Se‐Met or NAC treatment. Data are shown for individual (n = 4) and mean (bars) values and analysed by the Mann–Whitney U‐test. * P‐value < 0.05, ** P‐value < 0.01. Results are representative of three independent experiments.