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. 2021 Sep 7;15:683687. doi: 10.3389/fncel.2021.683687

FIGURE 6.

FIGURE 6

Human CNS microvasculature expresses IL-20 receptor subunits. Human microvessels were isolated from PVWM post-mortem biopsies, n = 3, to elucidate IL-20 receptor subunits protein expression by immunolabeling for IL-22RA1 (white), IL-20RB (red), IL-20RA (green), and DAPI (blue), scale bar = 10 μm (A). Histogram analysis was performed to 50 microvessels per specimen to determine AUI and AUC of each receptor subunit (representative AUI vs. axis plot histogram, B). Although AUC means exhibit a trend IL-22RA1 > IL-20RB > IL-20RA, one-way ANOVA analysis followed by Sidak’s post hoc test showed that mean AUC differences between subunits are not statistically significant (mean ± SD IL-22RA1: 1.2 × 10–3 ± 2.1 × 10–4, IL-20RB: 9.9 × 10–4 ± 2.0 × 10–4, and IL-20RA: 8.1 × 10–4 ± 1.7 × 10–4, C). Results are shown as mean ± SD.