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. 2021 Sep 7;11:703259. doi: 10.3389/fcimb.2021.703259

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Copyright © 2021 Feng, Duan, Gao, Zhang, Qiao, Li and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of cervical tissue transcriptome data of different viral infection statuses. (A) Differences in gene expression in the EBV and HPV coinfection groups compared with the HPV infection alone group (red and green dots indicate DEGs); the numbers in plots indicate the numbers of DEGs. (B) Hierarchical cluster analysis of DEGs within different paired comparisons confirming that patients with each infection or coinfection status could be grouped together based on similar gene expression profiles (red, upregulated; blue, downregulated). (C) Numbers of DEGs belonging to numerous significantly altered GO enrichment terms (up, upregulated DEGs; down, downregulated DEGs; total, total DEGs).