. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Brain Behav Immun. 2021 Jun 23;97:42–60. doi: 10.1016/j.bbi.2021.06.011

Table 5.

Statistical values for analyses performed within Figure 5. ATF3 localization datasets were analyzed using Ordinary Two-Way ANOVA with Tukey’s post hoc. Significance was set at p<0.05 for all datasets. Bolded values are statistically significant.

Dataset	Main Effect			Interactions		Multiple Comparisons

		F (DFn, DFd)	p-value	F (DFn, DFd)	p-value	Effect	Groups	p-value

ATF3 Localization	Na_v1.8+ Neurons	Genotype: F (3, 24) = 55.51 Sex: F (1, 24) = 43.95	p<0.0001 p<0.0001	F (3, 24) = 10.03	p=0.0002	Genotype	Males: Sham vs TLR4^LoxTB	p=0.4919
							Males: Sham vs Na_v1.8^TLR4LoxTB	p=0.3250
							Males: WT vs TLR4^LoxTB	p=0.0031
							Males: WT vs Na_v1.8^TLR4LoxTB	p=0.0064
							Males: Na_v1.8^TLR4LoxTB vs TLR4^LoxTB	p>0.9999
							Females: Sham vs TLR4^LoxTB	p=0.1037
							Females: Sham vs Na_v1.8^TLR4LoxTB	p<0.0001
							Females: WT vs TLR4^LoxTB	p<0.0001
							Females: WT vs Na_v1.8^TLR4LoxTB	p=0.9360
							Females: Na_v1.8^TLR4LoxTB vs TLR4^LoxTB	p<0.0001
						Sex	Male TLR4^LoxTB vs Female TLR4^LoxTB	p=0.8948
							Male TLR4^LoxTB vs Female Na_v1.8^TLR4LoxTB	p<0.0001
							Male Na_v1.8^TLR4LoxTB vs Female TLR4^LoxTB	p=0.9720
							Male Na_v1.8^TLR4LoxTB vs Female Na_v1.8^TLR4LoxTB	p<0.0001

	NF200+ Neurons	Genotype: F (3, 23) = 17.49 Sex: F (1, 23) = 2.067	p<0.0001 p=0.1639	F (3,23) = 1.088	p=0.3741	Genotype	Males: Sham vs TLR4^LoxTB	p=0.0035
							Males: Sham vs Na_v1.8^TLR4LoxTB	p=0.0402
							Males: WT vs TLR4^LoxTB	p>0.9999
							Males: WT vs Na_v1.8^TLR4LoxTB	p=0.9166
							Males: Na_v1.8^TLR4LoxTB vs TLR4^LoxTB	p=0.9797
							Females: Sham vs TLR4^LoxTB	p=0.0355
							Females: Sham vs Na_v1.8^TLR4LoxTB	p=0.0007
							Females: WT vs TLR4^LoxTB	p=0.1901
							Females: WT vs Na_v1.8^TLR4LoxTB	p=0.9888
							Females: Na_v1.8^TLR4LoxTB vs TLR4^LoxTB	p=0.5423