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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Brain Behav Immun. 2021 Jul 17;97:365–370. doi: 10.1016/j.bbi.2021.07.003

Figure 2.

Figure 2.

Effects of aging and miR-155 deletion on sensory thresholds at baseline and after SCI (Hargreaves heat – a-c; von Frey mechanical – d-f). a. At baseline, aged mice had reduced response latency to heat. There was no significant effect of miR-155 deletion. b-c. Both adult (b) and aged (c) mice after SCI displayed heat hyperalgesia at all times tested (7–28 dpo). miR-155 deletion did not modify SCI-elicited heat hypersensitivity. d. Baseline mechanical thresholds were not significantly altered in aged or miR-155 KO mice. e,f. Both adult and aged WT mice exhibited mechanical allodynia from 7–28 d after SCI. Adult miR-155 KO mice had ameliorated mechanical hypersensitivity at 7 and 14 dpo. † indicates p<0.05 group difference between adult and aged mice; colored + indicates p<0.05 within-genotype between pre- and post-SCI thresholds; * indicates p<0.05 between WT and KO mice.