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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Metabolism. 2021 Aug 13;123:154864. doi: 10.1016/j.metabol.2021.154864

Fig. 3. AMPD3 significantly alters the cellular metabolome independent of changes in gene expression.

Fig. 3

C2C12 myotubes were incubated with adenovirus encoding GFP or AMPD3+GFP for 24 h. (A) Volcano plot of significantly altered genes between AMPD3 and GFP controls as detected by RNAseq. n=3 (B) Heat map of significantly altered intracellular metabolites between AMPD3 and GFP as detected by metabolomics analysis. n=7 (C) Top 12 metabolic pathways altered by AMPD3 as determined by pathway enrichment analysis. (D) Heat map of significantly altered media metabolites between DMEM (untreated media), AMPD3 and GFP as detected by metabolomics analysis. n=3