5-year mortality (Panel A) and mortality differences in percentage points (Panel B) comparing mortality among 82,766 people entering care for HIV at a US NA-ACCORD clinical site between 1999 and 2004 (n = 32,588), 2005 and 2010 (n = 27,104), and 2011 and 2017 (n = 23,074) and a matched subset of the general US population. Bars represent 95% confidence intervals.