Table 1.
Size of Left Ventricle, Risk Region, and Infarct.
Age | Body | Heart | H/B | LV | RR | Infarct | RR | Infarct | Infarct | Shock | |
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(wk) | (g) | (mg) | (%) | (mg) | (mg) | (mg) | (% of LV) | (% of risk region) | (% of LV) | ||
GroupI (WT, AMI) | 14 ± 5 | 29.2 ± 3.9 | 161 ± 30 | 0.55 ± 0.06 | 119 ± 25 | 43 ± 11 | 26 ± 9 | 36.8 ± 7.9 | 58.6 ± 7.0 | 21.7 ± 5.9 | N/A |
Group II (WT, sham Ex) | 11 ± 1 | 28.5 ± 2.5 | 171 ± 12 | 0.60 ± 0.05 | 126 ± 12 | 43 ± 11 | 27 ± 8 | 34.1 ± 6.5 | 63.4 ± 7.8 | 21.5 ± 4.7 | 180 ± 51 |
Group III (WT, Ex) | 13 ± 2 | 29.0 ± 2.4 | 157 ± 20 | 0.54 ± 0.06 | 112 ± 17 | 34 ± 11 | 9 ± 5* | 29.5 ± 7.4 | 25.5 ± 8.8* | 7.8 ± 3.7* | 139 ± 74 |
Group IV (WT, Ex + NS) | 12 ± 3 | 27.2 ± 0.1.9 | 145 ± 13 | 0.54 ± 0.07 | 108 ± 15 | 30 ± 4 | 8 ± 4* | 28.2 ± 4.9 | 27.2 ± 14.0* | 7.3 ± 3.7* | 182 ± 62 |
Group V (WT, sham Ex + L-NA) | 18 ± 4 | 32.6 ± 5.2 | 151 ± 18 | 0.47 ± 0.06 | 116 ± 13 | 38 ± 3 | 19 ± 4 | 33.5 ± 4.0 | 50.2 ± 10.4 | 16.7 ± 3.2 | N/A |
Group VI (WT, Ex + L-NA) | 10 ± 1 | 29.1 ± 3.5 | 160 ± 24 | 0.55 ± 0.05 | 115 ± 17 | 42 ± 4 | 23 ± 6 | 36.8 ± 5.6 | 56.1 ± 16.2 | 20.3 ± 5.2 | 131 ± 75 |
Group VII (WT, Ex + DMSO) | 11 ± 1 | 27.9 ± 1.4 | 146 ± 9 | 0.52 ± 0.03 | 111 ± 11 | 33 ± 5 | 9 ± 4* | 29.9 ± 5.5 | 27.9 ± 13.4* | 8.2 ± 4.0* | 44 ± 28 |
Group VIII (WT, sham Ex + CHE) | 18 ± 4 | 34.5 ± 8.9 | 149 ± 29 | 0.44 ± 0.08 | 115 ± 22 | 42 ± 11 | 20 ± 7 | 36.3 ± 5.9 | 48.2 ± 8.5 | 17.3 ± 3.4 | N/A |
Group IX (WT, Ex + CHE) | 14 ± 5 | 29.5 ± 2.8 | 147 ± 12 | 0.50 ± 0.03 | 109 ± 10 | 35 ± 9 | 21 ± 8 | 32.4 ± 10.1 | 57.9 ± 12.5 | 19.2 ± 8.1 | 81 ± 14 |
Group X (WT, Ex +1400 W) | 11 ± 0 | 30.5 ± 2.1 | 175 ± 23 | 0.57 ± 0.05 | 134 ± 20 | 42 ± 11 | 26 ± 8 | 31.1 ± 5.2 | 62.0 ± 8.8 | 19.4 ± 4.6 | 127 ± 58 |
Group XI (eNOS−/−, AMI) | 24 ± 6 | 28.4 ± 3.5 | 156 ± 22 | 0.55 ± 0.09 | 119 ± 17 | 46 ± 11 | 28 ± 8 | 38.8 ± 6.9 | 59.7 ± 4.6 | 23.3 ± 5.0 | N/A |
Group XII (eNOS−/−, sham Ex) | 20 ± 2 | 26.7 ± 6.1 | 155 ± 24 | 0.59 ± 0.07 | 115 ± 15 | 46 ± 12 | 27 ± 6 | 40.1 ± 9.0 | 59.0 ± 9.6 | 23.2 ± 4.4 | 213 ± 24 |
Group XIII (eNOS−/−, Ex) | 18 ± 4 | 30.5 ± 2.2 | 179 ± 13 | 0.59 ± 0.05 | 128 ± 7 | 41 ± 16 | 26 ± 14 | 32.0 ± 11.6 | 61.0 ± 11.2 | 20.3 ± 10.0 | 173 ± 68 |
Group XIV (iNOS−/−, AMI) | 17 ± 4 | 30.8 ± 7.5 | 167 ± 46 | 0.54 ± 0.05 | 121 ± 30 | 44 ± 8 | 23 ± 6 | 38.0 ± 8.9 | 53.4 ± 11.2 | 20.3 ± 6.8 | N/A |
Group XV (iNOS−/−, sham Ex) | 16 ± 3 | 29.1 ± 5.0 | 142 ± 32 | 0.48 ± 0.05 | 107 ± 24 | 40 ± 9 | 25 ± 8 | 37.7 ± 7.2 | 63.8 ± 8.8 | 24.0 ± 5.2 | 105 ± 69 |
Group XVI (iNOS−/−, Ex) | 21 ± 4 | 28.4 ± 4.4 | 171 ± 18 | 0.61 ± 0.05 | 123 ± 15 | 44 ± 8 | 26 ± 10 | 36.0 ± 5.1 | 56.4 ± 12.9 | 20.8 ± 7.02.5 | 58 ± 39 |
Ex, exercise; Body, body weight; Heart, total heart weight (ventricles and atria); H/B, the ratio of heart weight with body weight; LV, left ventricle; RR, region at risk; Shock, number of shocks during acclimation. Data are means ± SD.
P < 0.05 vs. group II.