Table 4.

Stressful Life Events Across the Lifespan (Childhood ACEs from birth to age 15 and Stressful Life Events from age 21 to 26 and age 32 through 44) and suPAR at age 45

Outcome: suPAR at age 45
N = 828	β	95% CI	p	β	95% CI	p
Prospective ACEs	0.18	[0.11, 0.24]	< .001	0.10	[0.04, 0.17]	.002
Adult stressful life events	0.19	[0.13, 0.26]	< .001	0.12	[0.06, 0.19]	< .001
Sex				−0.15	[−0.21, −0.09]	< .001
Smoking at 45				0.28	[0.22, 0.34]	< .001
BMI at 45				0.14	[0.07, 0.20]	< .001
Anti-inflammatory medication use at 45				0.05	[−0.01, 0.11]	.111

Note: ACEs = adverse childhood experiences; BMI = body mass index; suPAR = soluble urokinase plasminogen activator receptor.