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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Contemp Clin Trials. 2021 Jul 25;108:106517. doi: 10.1016/j.cct.2021.106517

Figure 1:

Figure 1:

Operating characteristics of the accelerated titration design, 3+3 design, BOIN method, and CRM based on the simulation results in Ananthakrishnan et al. 10. Results are based on 10000 simulated trials for each method. The target DLT rate that defines the MTD is 0.20. The cohort size for BOIN and CRM is 3.