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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Contemp Clin Trials. 2021 Jul 25;108:106517. doi: 10.1016/j.cct.2021.106517

Figure 3:

Figure 3:

Operating characteristics for the design of Example 2 for each set of curves provided in Figure 2. The panels report (1) the probability of stopping for safety in Phase I, (2) the probability of stopping for safety in Phase II, (3) the probability of stopping for futility in Phase II, and (4) the probability of completing Phase II with evidence of improved response.