Table 2:

Cohort study data collection and outcomes for all participants

	Visit
Domain	Baseline	Follow up visit
		Week 6 of Intervention*	12-week P0I	6-months P0I	1-year P0I
Questionnaires
• Cognitive Function (MoCA)	X				X
• Demographics and lifestyle behaviors	X				X
• Medical History and medication inventory	X				X
• Depression (CES-D)	X				X
• Self-reported physical functioning (SF-36 PFI)	X
• Physical activity history (CHAMPS)	X		X	X	X
Physical and laboratory measurements
• Height	X	X	X		X
• Weight, waist circumference, waist-hip-ratio	X	X	X		X
• Heart rate (also monitored pre and post exercise in intervention participants)	X	X	X		X
• DXA scan for sarcopenia confirmation	X	X	X		X
• Muscle Strength: Grip strength, 1-Repetition maximum test	X	X	X		X
• Resting systolic and diastolic blood pressure (also monitored pre and post exercise in intervention participants	X	X	X		X
• Cardiovascular risk factors by non-fasting blood and serum specimens: blood lipids blood glucose, Insulin resistance (HOMA-IR), inflammation (IL-6)	X		X		X
• Physical performance measures: 6-meter gait speed, five time sit to stand test, 3-stage standing balance, timed up and go	X	X	X		X
• Endothelial Function via flow-induced vasodilation	X		X
Feasibility Process Measures
• Focus group conduct*			X
• Intervention Acceptability (monitored continuously during exercise intervention)*
• Recruitment and intervention process measures (monitored continuously)
• Safety of participants in the intervention arm (monitored continuously)
• Symptoms and adverse events (monitored continuously)

^*Data collected in intervention arm only

B₀, baseline; CES-D, Center for Epidemiologic Studies Depression Scale; CHAMPS, Community Healthy Activities Model Program for Seniors; HOMA-IR, homeostasis model assessment-estimated insulin resistance; IL-6, interleukin-6; MoCA, Montreal Cognitive Assessment; P₀I, post-intervention; SF-36 PFI, Short-Form Physical Function Index