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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Brain Behav Immun. 2021 Jul 8;97:102–118. doi: 10.1016/j.bbi.2021.07.002

Figure 3.

Figure 3.

Genetic deletion of LCN2 improves nest building during cancer cachexia, but not LPS challenge. (a) Experimental design for pancreatic tumor and LPS studies. (b) Nest building scores in male Lcn2-KO and WT mice after sham operation or tumor implantation (Average of 2 consecutive scoring days; n = 6–12 per group; WT sham vs. tumor, p=0.0267). (c) Nest building scores in Lcn2-KO and WT mice 24 hours after LPS treatment (n = 5–7 per group; Lcn2-KO vehicle vs LPS, p=0.0259). Data in b-c are expressed as mean ± SEM. Data represented in b-c were analyzed with two-way ANOVA with Bonferroni multiple comparisons per cell type. LPS dose was 1 mg/kg. *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001, ****p ≤ 0.0001. LPS = lipopolysaccharide; IP = intraperitoneal.