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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Brain Behav Immun. 2021 Jul 8;97:102–118. doi: 10.1016/j.bbi.2021.07.002

Figure 6.

Figure 6.

Cerebral LCN2 results in the recruitment of immune cells to the CNS. (a-h) Representative confocal images of the dentate gyrus and velum interpositum (VI) in mice treated with ICV vehicle or LCN2 after 4 or 10 days. 10x magnification; scale bar = 300μm. (i-j) Imaging and quantification of CD45+ and MPO+ cells in mice treated with either ICV vehicle or LCN2 after 4 or 10 days (n = 3–4 per group). (k-r) Flow cytometry analysis of immune cell populations using hemi-brains of mice treated with ICV vehicle or LCN2 after 4 or 10 days (n = 4 per group). Data in i-r are expressed as mean ± SEM. Data represented in i-r were analyzed by two-tailed Students t-tests amongst treatment groups. *p ≤ 0.05, **p ≤ 0.01. MPO = myeloperoxidase.