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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Brain Behav Immun. 2021 Jul 8;97:102–118. doi: 10.1016/j.bbi.2021.07.002

Figure 7.

Figure 7.

Primary hippocampal neurons respond to LCN2 in a temporal fashion, and prolonged exposure results in reduced neurite length. Differential gene expression assessed by RNA-seq in primary hippocampal neurons treated with LCN2 (100 ng/mL) or vehicle for either (a) 1 or (b) 4 days. (c) Gene ontology analysis performed on genes with increased expression after 4 days of LCN2 treatment. (d) Total neurite length, (e) number of neurons, and (f) average neurite length per neuron in a single field of view (FOV) of primary hippocampal neurons treated with 4 days of LCN2 (100 ng/mL) or vehicle (For f, p=0.0402). (g) Representative 10x field of view for neurons and neurites quantified in d-f (n = 26–27 fields per condition). Scale bar = 300μm.