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Chronic cerebral exposure to LCN2 results in similar, but not identical, gene set analyses in wild type and Mc4r-KO male mice. Volcano plot of neuropathology-related transcript expression in the hippocampus of LCN2-treated mice compared to vehicle-treated controls in (a) wild type or (c) Mc4r-KO mice using Nanostring™ Neuropathology gene panel. Concomitant gene set analyses of the top 12 regulated pathways in (b) wild type or (d) Mc4r-KO mice (n = 5–6 per group).
