Table 1.
MR results of causal links between gut microbiome and SLE risk (P < 1 × 10-5).
| Classification | Nsnp | Methods | Beta | SE | OR (95% CI) | P value | Horizontal pleiotropy | Heterogeneity | F statistic | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Egger intercept | SE | P value | Cochran’s Q | P value | |||||||||
| Class | Bacilli | 16 | MR Egger | 0.61 | 0.44 | 1.84 (0.77–4.38) | 0.189 | -0.02 | 0.03 | 0.519 | 19.63 | 0.142 | 24.73 |
| Weighted median | 0.46 | 0.21 | 1.59 (1.06–2.39) | 0.027 | |||||||||
| Inverse variance weighted | 0.34 | 0.16 | 1.40 (1.02–1.93) | 0.037 | |||||||||
| Weighted mode | 0.65 | 0.34 | 1.91 (0.98–3.75) | 0.078 | |||||||||
| Order | Lactobacillales | 14 | MR Egger | 0.22 | 0.44 | 1.24 (0.52–2.94) | 0.634 | 0.01 | 0.03 | 0.769 | 16.71 | 0.161 | 25.54 |
| Weighted median | 0.55 | 0.22 | 1.73 (1.13–2.64) | 0.011 | |||||||||
| Inverse variance weighted | 0.34 | 0.17 | 1.40 (1.01–1.95) | 0.045 | |||||||||
| Weighted mode | 0.57 | 0.33 | 1.78 (0.93–3.34) | 0.107 | |||||||||
| Bacillales | 11 | MR Egger | 0.07 | 0.30 | 1.08 (0.60–1.95) | 0.813 | -0.03 | 0.04 | 0.448 | 7.62 | 0.666 | 24.69 | |
| Weighted median | -0.22 | 0.09 | 0.81 (0.67–0.96) | 0.018 | |||||||||
| Inverse variance weighted | -0.16 | 0.07 | 0.85 (0.74–0.98) | 0.022 | |||||||||
| Weighted mode | -0.28 | 0.14 | 0.76 (0.57–1.01) | 0.080 | |||||||||
| Genus | Coprobacter | 12 | MR Egger | -0.01 | 0.38 | 0.99 (0.47–2.08) | 0.975 | -0.03 | 0.04 | 0.533 | 12.35 | 0.262 | 26.60 |
| Weighted median | -0.26 | 0.13 | 0.77 (0.59–0.99) | 0.043 | |||||||||
| Inverse variance weighted | -0.25 | 0.10 | 0.78 (0.64–0.95) | 0.014 | |||||||||
| Weighted mode | -0.40 | 0.24 | 0.67 (0.42–1.07) | 0.121 | |||||||||
| Eggerthella | 10 | MR Egger | 0.55 | 0.70 | 1.73 (0.44–6.79) | 0.453 | -0.03 | 0.08 | 0.675 | 19.35 | 0.022 | 22.42 | |
| Weighted median | 0.35 | 0.15 | 1.41 (1.05–1.90) | 0.022 | |||||||||
| Inverse variance weighted | 0.25 | 0.15 | 1.29 (0.95–1.74) | 0.097 | |||||||||
| Weighted mode | 0.36 | 0.18 | 1.43 (0.99–2.06) | 0.085 | |||||||||
| Lachnospira | 7 | MR Egger | -0.31 | 1.11 | 0.73 (0.08–6.48) | 0.790 | -0.01 | 0.07 | 0.861 | 8.21 | 0.145 | 10.83 | |
| Weighted median | -0.49 | 0.26 | 0.61 (0.37–1.02) | 0.059 | |||||||||
| Inverse variance weighted | -0.51 | 0.23 | 0.60 (0.38–0.94) | 0.027 | |||||||||
| Weighted mode | -0.49 | 0.37 | 0.61 (0.30–1.26) | 0.231 | |||||||||
| Ruminiclostridium6 | 11 | MR Egger | -1.04 | 0.43 | 0.35 (0.15–0.83) | 0.040 | 0.10 | 0.05 | 0.065 | 13.11 | 0.158 | 23.83 | |
| Weighted median | -0.37 | 0.22 | 0.69 (0.45–1.08) | 0.102 | |||||||||
| Inverse variance weighted | -0.20 | 0.19 | 0.82 (0.56–1.19) | 0.293 | |||||||||
| Weighted mode | -0.47 | 0.33 | 0.63 (0.33–1.21) | 0.193 | |||||||||
SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism; OR, odds ratio.