Table 2.
SNPs used as instrumental variables from gut microbiome and SLE GWASs (P < 1 × 10-5).
| Bacterial traits | SNP | Effect allele | Other allele | Gut microbiome | SLE | Proxy SNP | Target effect allele | Target other allele | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | P value | Beta | SE | P value | |||||||
| Bacilli | rs11110282 | A | G | -0.10 | 0.02 | 2.08E-06 | -0.01 | 0.07 | 0.888 | – | – | – |
| rs12642660 | A | G | -0.08 | 0.02 | 8.32E-07 | -0.11 | 0.04 | 0.014 | – | – | – | |
| rs12797734 | C | T | 0.06 | 0.01 | 5.58E-06 | 0.03 | 0.03 | 0.344 | – | – | – | |
| rs2370083 | G | T | -0.08 | 0.02 | 5.98E-06 | -0.09 | 0.05 | 0.068 | – | – | – | |
| rs28564647 | G | T | -0.06 | 0.02 | 5.98E-06 | 0.04 | 0.04 | 0.301 | – | – | – | |
| rs2952251 | G | A | -0.06 | 0.01 | 6.59E-07 | -0.05 | 0.04 | 0.160 | – | – | – | |
| rs35344081 | A | G | 0.06 | 0.01 | 9.35E-07 | -0.02 | 0.03 | 0.560 | – | – | – | |
| rs3911531 | C | T | -0.06 | 0.01 | 8.53E-06 | -0.01 | 0.04 | 0.800 | – | – | – | |
| rs4028634 | C | T | 0.05 | 0.01 | 3.08E-06 | 0.02 | 0.03 | 0.568 | – | – | – | |
| rs4459992 | C | T | 0.05 | 0.01 | 9.31E-06 | 0.05 | 0.03 | 0.096 | – | – | – | |
| rs4968759 | A | G | -0.05 | 0.01 | 9.14E-06 | 0.04 | 0.03 | 0.201 | – | – | – | |
| rs57872228 | C | T | -0.07 | 0.01 | 7.28E-07 | 0.01 | 0.04 | 0.821 | – | – | – | |
| rs694949 | G | A | -0.08 | 0.02 | 5.00E-06 | -0.08 | 0.05 | 0.078 | – | – | – | |
| rs7666190 | A | C | -0.10 | 0.02 | 7.60E-06 | 0.04 | 0.06 | 0.515 | – | – | – | |
| rs78938557 | C | T | 0.11 | 0.02 | 9.54E-07 | -0.04 | 0.06 | 0.505 | – | – | – | |
| rs9581006 | C | T | 0.23 | 0.05 | 1.80E-06 | 0.14 | 0.07 | 0.054 | – | – | – | |
| Lactobacillales | rs11110282 | A | G | -0.11 | 0.02 | 1.64E-06 | -0.01 | 0.07 | 0.888 | – | – | – |
| rs11627423 | A | C | 0.05 | 0.01 | 8.94E-06 | 0.03 | 0.03 | 0.374 | – | – | – | |
| rs11639594 | A | C | 0.05 | 0.01 | 9.53E-06 | 0.03 | 0.03 | 0.294 | – | – | – | |
| rs12642660 | A | G | -0.07 | 0.02 | 2.42E-06 | -0.11 | 0.04 | 0.014 | – | – | – | |
| rs12797734 | C | T | 0.06 | 0.01 | 6.07E-06 | 0.03 | 0.03 | 0.344 | – | – | – | |
| rs2370083 | G | T | -0.08 | 0.02 | 3.84E-06 | -0.09 | 0.05 | 0.068 | – | – | – | |
| rs2952251 | G | A | -0.06 | 0.01 | 2.00E-07 | -0.05 | 0.04 | 0.160 | – | – | – | |
| rs34989881 | A | G | 0.11 | 0.02 | 7.26E-06 | -0.11 | 0.06 | 0.081 | – | – | – | |
| rs35344081 | A | G | 0.06 | 0.01 | 3.70E-07 | -0.02 | 0.03 | 0.560 | – | – | – | |
| rs4028634 | C | T | 0.05 | 0.01 | 1.89E-06 | 0.02 | 0.03 | 0.568 | – | – | – | |
| rs57872228 | C | T | -0.07 | 0.01 | 2.08E-06 | 0.01 | 0.04 | 0.821 | – | – | – | |
| rs78938557 | C | T | 0.11 | 0.02 | 2.01E-06 | -0.04 | 0.06 | 0.505 | – | – | – | |
| rs7919839 | C | T | 0.08 | 0.02 | 8.97E-06 | -0.01 | 0.05 | 0.846 | – | – | – | |
| rs9581006 | C | T | 0.23 | 0.05 | 1.77E-06 | 0.14 | 0.07 | 0.054 | – | – | – | |
| Bacillales | rs10410917 | C | T | 0.11 | 0.02 | 5.50E-06 | -0.03 | 0.03 | 0.259 | – | – | – |
| rs821056 | A | G | 0.21 | 0.04 | 7.43E-06 | -0.01 | 0.04 | 0.789 | – | – | – | |
| rs11608727 | G | T | 0.13 | 0.03 | 6.17E-06 | 0.05 | 0.03 | 0.127 | – | – | – | |
| rs12498725 | A | G | -0.18 | 0.04 | 1.78E-06 | 0.01 | 0.04 | 0.782 | – | – | – | |
| rs182923 | T | C | 0.14 | 0.03 | 4.61E-06 | -0.05 | 0.04 | 0.214 | – | – | – | |
| rs4617108 | A | G | 0.25 | 0.05 | 1.04E-06 | -0.05 | 0.06 | 0.377 | – | – | – | |
| rs55793055 | C | T | -0.11 | 0.03 | 7.79E-06 | 0.04 | 0.03 | 0.126 | – | – | – | |
| rs62141894 | A | G | 0.14 | 0.03 | 6.90E-06 | -0.02 | 0.03 | 0.556 | – | – | – | |
| rs62640857 | A | G | 0.15 | 0.03 | 3.58E-06 | -0.04 | 0.04 | 0.346 | – | – | – | |
| rs7611581 | G | T | -0.11 | 0.02 | 3.00E-06 | 0.03 | 0.02 | 0.231 | – | – | – | |
| rs875142 | A | G | 0.13 | 0.03 | 5.13E-06 | -0.04 | 0.03 | 0.181 | – | – | – | |
| Coprobacter | rs11532348 | C | T | -0.10 | 0.02 | 4.34E-06 | -0.01 | 0.03 | 0.753 | – | – | – |
| rs12684609 | C | T | 0.10 | 0.02 | 5.70E-06 | -0.02 | 0.03 | 0.487 | – | – | – | |
| rs12996055 | A | C | 0.09 | 0.02 | 5.03E-06 | -0.04 | 0.03 | 0.229 | – | – | – | |
| rs143180826 | C | T | 0.17 | 0.04 | 6.60E-06 | 0.05 | 0.06 | 0.431 | – | – | – | |
| rs143662916 | C | T | 0.25 | 0.05 | 3.07E-06 | -0.11 | 0.07 | 0.143 | – | – | – | |
| rs189356 | A | G | 0.08 | 0.02 | 7.59E-06 | -0.05 | 0.03 | 0.071 | – | – | – | |
| rs213863 | C | T | -0.09 | 0.02 | 3.78E-06 | 0.04 | 0.03 | 0.217 | – | – | – | |
| rs28402691 | C | T | 0.11 | 0.02 | 7.14E-06 | 0.02 | 0.03 | 0.493 | – | – | – | |
| rs305411 | A | G | 0.13 | 0.03 | 8.82E-07 | -0.08 | 0.05 | 0.082 | – | – | – | |
| rs3828477 | G | T | -0.09 | 0.02 | 2.41E-06 | 0.04 | 0.03 | 0.220 | – | – | – | |
| rs72821405 | C | T | -0.15 | 0.03 | 4.27E-06 | 0.01 | 0.04 | 0.816 | – | – | – | |
| rs74919520 | A | G | 0.12 | 0.03 | 6.39E-06 | -0.11 | 0.05 | 0.021 | – | – | – | |
| Eggerthella | rs112205261 | C | T | -0.19 | 0.04 | 3.48E-06 | 0.13 | 0.06 | 0.032 | – | – | – |
| rs116603267 | A | G | 0.16 | 0.04 | 8.39E-06 | -0.07 | 0.06 | 0.221 | – | – | – | |
| rs1784446 | G | A | 0.09 | 0.02 | 5.05E-06 | -0.07 | 0.03 | 0.019 | – | – | – | |
| rs2223081 | G | A | 0.10 | 0.02 | 3.04E-06 | 0.02 | 0.03 | 0.563 | – | – | – | |
| rs2240838 | A | G | 0.09 | 0.02 | 1.46E-06 | 0.05 | 0.03 | 0.085 | – | – | – | |
| rs3851328 | G | T | -0.11 | 0.02 | 1.38E-06 | 0.04 | 0.03 | 0.215 | – | – | – | |
| rs4985746 | A | G | 0.11 | 0.02 | 4.63E-06 | -0.08 | 0.04 | 0.020 | – | – | – | |
| rs6430926 | C | T | 0.09 | 0.02 | 6.10E-06 | 0.03 | 0.03 | 0.247 | – | – | – | |
| rs6678488 | A | C | 0.09 | 0.02 | 6.20E-06 | -0.02 | 0.04 | 0.587 | – | – | – | |
| rs76663501 | C | T | 0.17 | 0.04 | 5.97E-06 | -0.08 | 0.06 | 0.179 | – | – | – | |
| Lachnospira | rs13157098 | A | G | -0.08 | 0.02 | 8.76E-07 | -0.06 | 0.05 | 0.196 | – | – | – |
| rs159484 | A | G | 0.08 | 0.02 | 7.37E-06 | -0.03 | 0.04 | 0.495 | – | – | – | |
| rs2520509 | G | A | 0.05 | 0.01 | 8.52E-06 | -0.06 | 0.03 | 0.032 | – | – | – | |
| rs4686798 | C | T | 0.05 | 0.01 | 4.51E-06 | -0.03 | 0.03 | 0.248 | – | – | – | |
| rs4923324 | A | G | -0.06 | 0.01 | 1.63E-06 | 0.07 | 0.03 | 0.031 | – | – | – | |
| rs56791201 | C | T | 0.05 | 0.01 | 2.77E-06 | -0.01 | 0.02 | 0.626 | – | – | – | |
| rs75566846 | A | C | 0.12 | 0.03 | 5.88E-06 | -0.11 | 0.07 | 0.152 | – | – | – | |
| Ruminiclostridium6 | rs10829821 | C | T | -0.10 | 0.02 | 4.89E-06 | -0.02 | 0.06 | 0.728 | rs11017525 | A | G |
| rs116969552 | A | G | -0.17 | 0.04 | 8.01E-06 | 0.05 | 0.08 | 0.533 | – | – | – | |
| rs11992182 | A | C | 0.06 | 0.01 | 2.69E-06 | 0.05 | 0.03 | 0.095 | – | – | – | |
| rs1377110 | G | A | 0.06 | 0.01 | 2.20E-06 | 0.03 | 0.04 | 0.416 | – | – | – | |
| rs61060922 | G | T | 0.16 | 0.03 | 8.98E-07 | -0.19 | 0.06 | 0.002 | – | – | – | |
| rs663262 | C | T | -0.13 | 0.03 | 3.63E-06 | -0.06 | 0.06 | 0.312 | – | – | – | |
| rs67479537 | C | T | 0.12 | 0.03 | 5.85E-06 | -0.07 | 0.06 | 0.236 | – | – | – | |
| rs71414120 | G | T | 0.20 | 0.04 | 8.77E-07 | -0.08 | 0.06 | 0.179 | – | – | – | |
| rs72991535 | G | T | 0.14 | 0.03 | 3.42E-06 | -0.07 | 0.07 | 0.306 | – | – | – | |
| rs79968172 | A | G | 0.11 | 0.02 | 2.23E-06 | 0.07 | 0.06 | 0.244 | – | – | – | |
| rs9555756 | A | C | -0.08 | 0.02 | 3.73E-06 | 0.05 | 0.04 | 0.194 | – | – | – | |
SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism.