Figure 1.

Binding of the tau tracers ³H-PI2620, ³H-MK6240, ³H-RO948 and ³H-JNJ067 to the frontal cortex from age-matched controls, Alzheimer’s disease cases, an FTDP-17 case with a MAPT R406W mutation and PSP cases. (A) Immunohistochemistry with AT8 and tracer binding in adjacent tissue sections of representative cases. Scale bar = 10 mm. (B) Total (filled circles) and non-specific (open circles) tracer binding to the grey matter expressed in Bq/cm². AD = Alzheimer’s disease; CTRL = age-matched control; GM/WM, grey-to-white matter ratio based on total tracer binding in these areas of interest; R406W = FTDP-17 due to a missense mutation in MAPT.