Table 1.

IC₅₀ values (mg/L) for antibiotic inhibition of protein synthesis and 50S subunit formation in different microorganisms

Organism	Antibiotic	Protein synthesis	50S synthesis	References
S. aureus
	erythromycin	0.17	0.36	92
	clarithromycin	0.075	0.15	92
	azithromycin	2.5	5.0	92
	telithromycin	0.04	0.08	92
	cethromycin	0.022	0.035	92
	solithromycin	0.04	0.065	115
	evernimicin	0.03	0.4	92
	TAN1057A	4.5	9.0	92
	linezolid	0.3	0.6	92
	retapamulin	0.05	0.27	112
	neomycin	1.25	3.0	92
	paromomycin	3.0	2.75	92
S. pneumoniae
	telithromycin	0.0075	0.015	114
	cethromycin	0.0025	0.005	113
	solithromycin	0.0075	0.015	115
H. influenzae
	erythromycin	1.5	8.0	92
	azithromycin	0.4	0.8	92
	clarithromycin	5.6	9.0	92
	fluorithromycin	6.0	8.0	92
	roxithromycin	9.0	12.5	92
	telithromycin	1.25	2.5	92
	cethromycin	1.25	2.5	92
	solithromycin	0.125	0.23	115
E. coli
	hygromycin B	16	65	133
	neomycin	3.6	7.2	92
	paromomycin	3.2	6.4	92

IC₅₀ values were determined by measuring the concentration-dependent inhibition by each antibiotic in the process listed for each microorganism. Data were from assays similar to those shown in Figure 3. Republished with permission from Bentham Science Publishers Ltd from reference 92.