Table 3.

Relative rates of ribosomal subunit synthesis in antibiotic-inhibited cells

			Synthesis time (min)
Organism	Antibiotic	Concentration (mg/L)	30S	50S	References
S. aureus
	none	0	10	20	92
	solithromycin	0.04	40	240	115
	evernimicin	0.32	10	240	92
	TAN1057A	5.0	10	120	29
	linezolid	0.5	20	60	92
	neomycin	3.0	120	240	92
	paromomycin	3.0	180	360	92
S. pneumoniae
	none	0	60	120	113
	cethromycin	0.002	180	180	113
	telithromycin	0.008	90	180	114
	solithromycin	0.008	60	60	115
H. influenzae
	none	0	15	30	92
	erythromycin	2.0	100	240	92
	azithromycin	0.3	60	200	92
	clarithromycin	5.0	30	60	92
	fluorithromycin	5.0	60	120	92
	roxithromycin	6.0	60	120	92
	solithromycin	0.125	45	200	115
E. coli
	none (37°C)	0	7.5	15	25
	hygromycin B	50	60	120	94
	erythromycin	75	7.5	90	25
	none (27°C)	0	15	30	97
	neomycin (27°C)	4.0	30	75	97
	paromomycin (27°C)	4.0	30	30	97

Subunit synthesis times were calculated from pulse-and-chase assays similar to those shown in Figure 6. Republished with permission from Bentham Science Publishers Ltd from reference 92.