Table 4.
Effect of antibiotic combinations on cell viability, protein synthesis and ribosomal subunit biogenesis in S. aureus cells
| Antibiotic | Cell viabilitya | Protein synthesisb | 30S subunit synthesisc | 50S subunit synthesisd |
|---|---|---|---|---|
| Control | 100 | 100 | 16.5 | 28.4 |
| AZM | 92 | 41.3 | 14.0 | 21.5 |
| RIF | 66 | 89.5 | 4.4 | 6.0 |
| CIP | 1.8 | 50.8 | 11.4 | 21.5 |
| AZM/RIF | 24 | 19.8 | 11.4 | 14.1 |
| RIF/CIP | 5.0 | 12.6 | 14.7 | 20.1 |
| AZM/CIP | 0.5 | 37.0 | 11.5 | 13.5 |
| AZM/RIF/CIP | 7.5 | 19.4 | 11.4 | 15.5 |
AZM, azithromycin; RIF, rifampicin; CIP, ciprofloxacin. Adapted from reference 127.
a
Percentage of control cfu/mL.
b
Percentage of control protein synthesis rate.
c
Percentage of total 30S.
d
Percentage of total 50S.