Figure 1.

Distribution of doravirine fold change (FC) values measured with clones harbouring NNRTI resistance-associated mutations (RAMs), as grouped by (a) number of NNRTI RAMs (linear test for trend, P = 0.005); (b) predicted doravirine susceptibility by the Stanford HIVdb algorithm; (c) predicted doravirine susceptibility by the ANRS algorithm. S, susceptible; I, intermediate resistance; R, high-level resistance. The dotted line indicates the biological FC cut-off (3-fold) recently established for doravirine.¹⁰