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. 2020 May 19;35(6):1262–1266. doi: 10.1093/humrep/deaa064

Figure 2.

Figure 2

Directed acyclic graph showing assumptions of confounding for assessing mediation. There may be a scenario where there was additional confounding both between the exposure and the mediator (Ue) and/or between the mediator and the outcome (Um).