Figure 1.

Immunostaining pattern in patients with KLHL11-Abs. Reactivity of rat brain tissue using a negative control (row 1) and with patient CSF positive for KLHL11-Abs (rows 2, 3 and 4). The CSF of patients showed extensive and diffuse immunostaining involving the cerebellar cortex and nuclei, putamen and hippocampus (in particular, the CA3 region, with a ‘comb-like’ staining). In the cerebellum and basal ganglia the immunostaining showed a ‘leopard-like’ appearance. For comparison, immunostaining using a commercial KLHL11-Abs is also shown (row 5), highlighting the involvement of the same regions.