Comparison 6. Subgroup Analysis: Type of Fluoride.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 No. People with new vertebral fractures‐2 years	4	1033	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.96 [0.72, 1.28]
1.1 NaF	3	531	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.87 [0.60, 1.28]
1.2 MFP	2	502	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.08 [0.70, 1.68]
2 No. People with new vertebral fractures 4 years	5	646	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.81 [0.55, 1.20]
2.1 NaF	4	446	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.70 [0.46, 1.05]
2.2 MFP	1	200	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.73 [1.15, 19.41]
3 Lumbar BMD % 2 years from baseline	7	1094	Mean Difference (IV, Fixed, 95% CI)	8.95 [8.18, 9.72]
3.1 NaF	4	533	Mean Difference (IV, Fixed, 95% CI)	10.48 [9.24, 11.71]
3.2 MFP	4	561	Mean Difference (IV, Fixed, 95% CI)	7.99 [7.01, 8.97]
4 Lumbar BMD % 4 years from baseline	3	501	Mean Difference (IV, Fixed, 95% CI)	14.87 [13.39, 16.35]
4.1 NaF	2	301	Mean Difference (IV, Fixed, 95% CI)	34.57 [31.13, 38.01]
4.2 MFP	1	200	Mean Difference (IV, Fixed, 95% CI)	10.40 [8.76, 12.04]
5 GI minor overall	9	1291	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.46 [1.11, 1.92]
5.1 NaF	7	856	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.02 [1.38, 2.94]
5.2 MFP	3	435	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.01 [0.67, 1.51]
6 GI minor 2 years	4	682	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.03 [0.74, 1.43]
6.1 NaF	2	247	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.09 [0.62, 1.90]
6.2 MFP	3	435	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.01 [0.67, 1.51]
7 GI minor 4 years	5	609	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.38 [2.02, 5.64]
7.1 NaF	5	609	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.38 [2.02, 5.64]
7.2 MFP	0	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Non vertebral fractures overall	5	1096	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.87 [1.35, 2.60]
8.1 NaF	4	615	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.42 [1.61, 3.63]
8.2 MFP	2	481	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.19 [0.69, 2.04]
9 Non vertebral fractures 2 years	1	500	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.23 [0.72, 2.11]
9.1 NaF	1	219	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.21 [0.52, 2.83]
9.2 MFP	1	281	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.24 [0.62, 2.50]
10 Non vertebral fractures 4 years	4	596	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.38 [1.59, 3.58]
10.1 NaF	3	396	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.96 [1.87, 4.70]
10.2 MFP	1	200	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.10 [0.46, 2.62]
11 Lower limb pain syndrome	6	1153	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.97 [2.81, 5.61]
11.1 NaF	5	778	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.19 [2.81, 6.26]
11.2 MFP	2	375	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.41 [1.73, 6.72]
12 Withdrawals and dropouts overall	8	805	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.97 [0.70, 1.34]
12.1 NaF	6	529	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.94 [0.62, 1.44]
12.2 MFP	2	276	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.01 [0.61, 1.67]
13 Withdrawals and dropouts 2 years	4	219	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.03 [0.54, 1.96]
13.1 NaF	2	83	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.69 [0.20, 2.35]
13.2 MFP	2	136	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.20 [0.56, 2.58]
14 Withdrawals and dropouts 4 years	5	646	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.96 [0.67, 1.36]
14.1 NaF	4	446	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.98 [0.63, 1.54]
14.2 MFP	1	200	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.92 [0.52, 1.62]