Comparison 8. Sensitivity Quality.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 No. People with new vertebral fractures‐2 years	4	742	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.95 [0.68, 1.32]
1.1 Low quality	4	742	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.95 [0.68, 1.32]
1.2 High quality	0	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 No. Peiple with new vertebral fractures 4 years	5	646	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.64 [0.43, 0.94]
2.1 Low quality	3	362	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.57 [0.36, 0.90]
2.2 High quality	2	284	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.86 [0.41, 1.82]
3 Lumbar BMD % 2 years from baseline	7	1002	Mean Difference (IV, Fixed, 95% CI)	9.73 [8.82, 10.65]
3.1 Low quality	6	802	Mean Difference (IV, Fixed, 95% CI)	13.14 [11.55, 14.73]
3.2 High quality	1	200	Mean Difference (IV, Fixed, 95% CI)	8.04 [6.92, 9.16]
4 Lumbar BMD % 4 years from baseline	3	501	Mean Difference (IV, Fixed, 95% CI)	14.87 [13.39, 16.35]
4.1 Low quality	2	301	Mean Difference (IV, Fixed, 95% CI)	34.57 [31.13, 38.01]
4.2 High quality	1	200	Mean Difference (IV, Fixed, 95% CI)	10.40 [8.76, 12.04]
5 GI minor overall	9	1145	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.56 [1.15, 2.11]
5.1 Low quality	8	1061	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.48 [1.07, 2.03]
5.2 High quality	1	84	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.64 [1.00, 6.97]
6 GI minor 2 years	4	536	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.04 [0.71, 1.51]
6.1 Low quality	4	536	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.04 [0.71, 1.51]
6.2 High quality	0	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 GI minor 4 years	5	609	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.38 [2.02, 5.64]
7.1 Low quality	4	525	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.71 [2.03, 6.79]
7.2 High quality	1	84	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.64 [1.00, 6.97]
8 Non vertebral fractures overall	5	950	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.96 [1.39, 2.75]
8.1 Low quality	3	666	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.26 [1.51, 3.37]
8.2 High quality	2	284	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.33 [0.69, 2.56]
9 Non vertebral fractures 2 years	1	354	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.22 [0.65, 2.30]
9.1 Low quality	1	354	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.22 [0.65, 2.30]
9.2 High quality	0	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
10 Non vertebral fractures 4 years	4	596	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.38 [1.59, 3.58]
10.1 Low quality	2	312	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.43 [2.04, 5.77]
10.2 High quality	2	284	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.33 [0.69, 2.56]
11 Withdrawals and dropouts overall	9	865	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.97 [0.71, 1.33]
11.1 Low quality	6	526	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.06 [0.70, 1.60]
11.2 High quality	3	339	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.87 [0.55, 1.40]
12 Lower limb pain syndrome	6	1007	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.69 [2.59, 5.26]
12.1 Low quality	5	923	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.23 [2.87, 6.23]
12.2 High quality	1	84	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.89 [0.80, 4.48]
13 Withdrawals and dropouts 2 years	4	219	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.03 [0.54, 1.96]
13.1 Low quality	3	164	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.02 [0.51, 2.07]
13.2 High quality	1	55	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.04 [0.19, 5.59]
14 Withdrawals and dropouts 4 years	5	646	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.96 [0.67, 1.36]
14.1 Low quality	3	362	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.08 [0.65, 1.80]
14.2 High quality	2	284	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.86 [0.53, 1.40]