Pak 1995.

Methods	RCT duration 48 months54 patients in fluoride group and 56 in control group
Participants	110 postmenopausal osteoporotic women in USA age 67.6 duration of menopause 19.2 race NA
Interventions	Na F 27.5 mg element (low dose), non enteric‐coated, slow ‐releaseassociated treatment calcium with or without HRTversus placebo
Outcomes	vertebral and non vertebral fractures , BMD femoral neck and forearm, BMC lumbar, GI side effects
Notes	quality score 2 randomization 1 blinding 0 withdrawals and dropouts 1
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear