FIGURE 2.

Effects of sulfonylurea drugs on action potentials (APs) during simulated ischemia (SI)A, Typical AP duration (APD) changes in time in response to SI in absence (top panels) or presence (bottom panels) of 10 nM glibenclamide. SI‐induced APD shortening is less pronounced in presence of glibenclamide. B, Average SI‐induced APD changes in time (left panel) and average APD shortening at 15 min in absence or presence of glibenclamide (10 nM), gliclazide (10 μM), glimepride (10 nM), and tolbutamide (10 μM). * indicates P < .05