Fig. 1.

Spline curves demonstrating the probability of significant renal impairment (eGFR <60 mL min⁻¹ 1.73 m⁻²) according to TAPSE in unadjusted (a) and adjusted models (b). The curve in panel a demonstrates the probability of significant renal impairment according to TAPSE measured at the time of index echocardiogram, with overlaid 95% confidence intervals displayed (shaded blue areas). The curve in panel b demonstrates the probability of significant renal impairment according to values of TAPSE, adjusted for age, diabetes mellitus, hypertension, ACEi/ARB use, diuretic use, aldosterone antagonist use, LV end‐diastolic volume, LV ejection fraction, the presence of significant MR, RV end‐diastolic area, tricuspid annulus diameter, TR regurgitant volume, estimated RAP and PASP. ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; eGFR, estimated glomerular filtration rate; LV, left ventricle; MR, mitral regurgitation; PASP, pulmonary artery systolic pressure; RAP, right atrial pressure; RV, right ventricle; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation.