TABLE 6.
Summary of the specific advantages of combination treatments in maintenance
| Combination | Comparison treatment | Manic relapse | Depressive relapse | Inter‐episodic symptoms |
|---|---|---|---|---|
| Valproic acid + Lithium | Valproic acid | + | +/− | – |
| Valproic acid + Lithium | Lithium | +/− | – | – |
| Valproic acid + Lithium | CBZ + Lithium | – | – | – |
| Lamotrigine + Valproic acid | Lamotrigine | +/− | + | – |
| Lamotrigine + Lithium | Lithium | – | +/− | – |
| Lamotrigine + Lithium | Olanzapine + lithium | – | – | +/−a |
| Aripiprazole + Lamotrigine | Lamotrigine | +/− | – | – |
| Quetiapine + Lamotrigine | Quetiapine | +/− | – | – |
| Asenapine + Lithium or Valproic acid | Lithium or Valproic acid | – | – | – |
+: clear advantage; +/−: possible advantage; –: no advantage/no data/inconclusive data; CBZ, Carbamazepine.
a
Advantage given by the comparison treatment.