TABLE 2.
Univariate analysis of laboratory factors associated with persistent chronic GVHD
| Persistent cGVHD (>7 years from diagnosis) N = 38 |
Early cGVHD (<1 year from diagnosis) N = 83 |
P value | |
|---|---|---|---|
| Platelet count, 109/L (median) | 277.5 | 193 | <.0001 |
| ESR, mm/hr (median) | 15 | 18.5 | .44 |
| CRP, mg/L (median) | 2.175 | 1.43 | .27 |
| C3, mg/dL (median) | 140.5 | 128 | .03 |
| C4, mg/dL (median) | 28.5 | 27 | .14 |
| Albumin, g/dL (median) | 4 | 3.5 | <.0001 |
| Ferritin, ng/mL (median) | 150 | 1240 | <.0001 |
| CD3, cells/μL (median) | 897.5 | 691 | .15 |
| CD4, cells, μL (median) | 533.5 | 327 | .002 |
| CD8, cells μL (median) | 320.5 | 310 | .88 |
| CD19, cells μL (median) | 265.5 | 87 | <.001 |
| NK, cells/μL (median) | 170.5 | 144.5 | .03 |
| IgG, mg/dL (median) | 756 | 516 | <.001 |
| IgM, mg/dL (median) | 70 | 49 | .007 |
| IgA, mg/dL (median) | 145 | 32 | <.0001 |
| Presence of autoantibodies (%) | |||
| Anti-CCP* | 5 (13%) | 4 (5%) | .151 |
| Anti-dsDNA* | 0 (0%) | 2 (3%) | 1.0000 |
| Anti-LKM-1* | 19 (50%) | 25 (32%) | .068 |
| Anti-mitochondrial | 3 (8%) | 10 (13%) | .545 |
| ANA* | 14 (37%) | 17 (21%) | .0789 |
| ENA * | 7 (18%) | 1 (1%) | .001 |
| Anti-cardiolipin IgM | 6 (16%) | 3 (4%) | .057 |
| Anti-cardiolipin IgG | 1 (3%) | 7 (9%) | .272 |
| Rheumatoid Factor | 5 (14%) | 5 (6%) | .284 |
*
CCP-1: Citric citrullinated peptide, dsDNA: double stranded DNA, LKM-1: Liver-kidney microsomal type 1, ANA: anti-nuclear antibody, ENA: Extractable nuclear antigen.