Table 2.
Clinical Correlates of Phosphatidylserine Immunoglobulin M and Immunoglobulin G Antibodies in Patients With Malaria
| Plasmodium falciparum (n = 269) | Plasmodium vivax (n = 176) | |||||||
|---|---|---|---|---|---|---|---|---|
| PS IgM | PS IgG | PS IgM | PS IgG | |||||
| Clinical Correlate | Correlation | P Value | Correlation | P Value | Correlation | P Value | Correlation | P Value |
| Hb on enrollment | –0.27 | < .0001a | –0.26 | < .0001a | –0.30 | .001 | –0.31 | < .0001a |
| Hb nadir | –0.28 | < .0001a | –0.29 | < .0001a | –0.34 | < .0001 | –0.35 | < .0001a |
| Parasite count | –0.00 | .943 | 0.01 | .824 | 0.10 | .170 | 0.10 | .192 |
| Fever duration | 0.30 | < .0001 | 0.11 | .078 | 0.22 | .004 | 0.15 | .051 |
| Age | 0.11 | .067 | –0.06 | .358 | –0.21 | .005 | –0.23 | .002 |
| CFHbb | 0.19 | .014 | 0.27 | .027 | 0.04 | .779 | –0.07 | .601 |
| RBC-Dc (at 1.7 Pa) | –0.28 | .008 | –0.13 | .227 | 0.22 | .282 | –0.04 | .859 |
| RBC-Dc (at 30 Pa) | –0.21 | .050 | –0.18 | .085 | –0.05 | .828 | –0.28 | .176 |
Abbreviations: CFHb, cell-free hemoglobin; Hb, hemoglobin; IgG, immunoglobulin G; IgM, immunoglobulin M; PS, phosphatidylserine; RBC-D, red blood cell deformability.
aRemained significant after controlling for parasitemia, fever duration, and age (Supplementary Table 1).
bCFHb was measured in 133 patients with falciparum malaria and 57 with vivax malaria.
cRBC-D was measured in 90 patients with falciparum malaria, and 25 patients with vivax malaria.