Table 3.
Antiphosphatidylserine Immunoglobulin M and Immunoglobulin G Antibodies in Volunteers With Experimental Malaria Infection
| Parameters | Plasmodium falciparum (n = 23) | Plasmodium vivax (n = 8) | P Value |
|---|---|---|---|
| Peak parasitemia, parasites/mL | 36 074 (8351–142 519) | 219 136 (112 091–308 113) | .008 |
| Baseline Hb, g/dL, mean (SD) | 14.8 (9.2) | 14.5 (7.3) | .456 |
| Hb day 18 (Pv) or day 20–28a (Pf), g/dL, mean (SD) | 13.5 (9.2) | 13.7 (7.9) | .786 |
| Hb decline, g/dL | 1.0 (0.6–1.5) | 1.0 (0.7–1.2) | .651 |
| PS IgM, day 0. U/mL | 21 (15–36) | 35 (20–70) | .124 |
| PS IgG, day 0, U/mL | 15 (6–24) | 20 (10–25) | .329 |
| PS IgM, day 18 (Pv) or day 20 (Pf), U/mL | 33 (27–52) | 71 (56–121) | .012 |
| PS IgG, day 18 (Pv) or day 20 (Pf), U/mL | 17 (3–24) | 24 (20–42) | .026 |
Data are presented as median (interquartile range) unless otherwise indicated.
Abbreviations: Hb, hemoglobin; IgG, immunoglobulin G; IgM, immunoglobulin M; Pf, Plasmodium falciparum; Pv, Plasmodium vivax; PS, phosphatidylserine; SD, standard deviation.
aFor volunteers with falciparum malaria, “Hb day 20–28” refers to hemoglobin measured on day 20, or the first available up to day 28.