Table 2. GCase Inhibition and IC50 Values in Human Leukocytes from Healthy Donors.
| entry | compound | GCase inhibition [%]a | IC50 (μM)b |
|---|---|---|---|
| 1 | 9 | 98 | 30.0 ± 1.0c |
| 2 | 11 | 80 | 93.5 ± 5.3d |
| 3 | 12 | 100 | 29.3 ± 1.8d |
| 4 | 14 | 100 | 100.0 ± 9.0 |
| 5 | 15 | 100 | 15.0 ± 4.0 |
| 6 | 33·HCl | 75 | 130 ± 15 |
a
Percentage inhibition of GCase in human leukocytes extracts incubated with azasugars (1 mM).
b
IC50 values were determined by measuring GCase activity at different concentrations of each inhibitor.
c
Ref (12) (IC50 value obtained using the same experimental protocol and substrate concentration of this manuscript).