Table 1.
Demographic and clinical features intent-to-treat samples.
| Active TBS (n=25) | Sham TBS (n=25) | p valuea | |
|---|---|---|---|
| Demographic Variables | |||
| Age (years, SD) | 48.6 (12.8) | 53.2 (11.6) | 0.19 |
| Sex, N (%) female | 5 (20) | 3 (12) | 0.44 |
| Race, n (%)b | 0.35 | ||
| Caucasian/White | 22 (88) | 20 (80) | |
| African American | 0 (0) | 2 (8) | |
| American Indian/Alaskan Native | 1 (4) | 0 (0) | |
| Multiracial | 2 (8) | 1 (4) | |
| Ethnicity, n (%)b | 0.37 | ||
| Hispanic origin | 0 (0) | 2 (8) | |
| Not of Hispanic origin | 23 (92) | 23 (92) | |
| Education, n (%)b | 0.15 | ||
| Less than high school | 1 (4) | 1 (4) | |
| High school or equivalent | 2 (8) | 5 (20) | |
| Some college | 11 (44) | 7 (28) | |
| Trade or vocational degree | 3 (12) | 0 (0) | |
| Bachelor’s degree | 2 (8) | 8 (32) | |
| Advanced degree and/or education beyond college | 2 (8) | 3 (12) | |
| Employment status, n (%)b | 0.80 | ||
| Full time | 6 (24) | 4 (16) | |
| Part time | 1 (4) | 2 (8) | |
| Unemployed | 10 (40) | 9 (36) | |
| Retired | 6 (24) | 9 (36) | |
| Service connected disability, n (%) approved for mental health | 14 (56) | 17 (68) | |
| Military History | |||
| Branch, n (%)b | 0.61 | ||
| Army | 8 (32) | 8 (32) | |
| Navy | 8 (32) | 6 (24) | |
| Marines | 2 (8) | 1 (4) | |
| Air Force | 0 (0) | 3 (12) | |
| Clinical Variables (mean, SD) | |||
| PTSD CAPS-5 Score | 47.4 (10.6) | 47.9 (10.0) | 0.85 |
| PTSD PCL-5 Score | 49.4 (9.4) | 50.0 (11.4) | 0.85 |
| Psychiatric Comorbidity, n (%) | 47.4 (10.6) | 47.9 (10.0) | 0.80 |
| Major Depressive Disorderc | 25 (100) | 25 (100) | 1.00 |
| Bipolar II, most recent episode depressed | 2 (8) | 3 (12) | 0.64 |
| Substance Use Disorder (Mild) | 16 (64) | 11 (44) | 0.16 |
| Opioid use disorder | 6 (24) | 5 (20) | 0.73 |
| Prior brain stimulation, n (%) | |||
| Transcranial Magnetic Stimulation | 0 (0) | 2 (8) | 0.15 |
| Electroconvulsive Therapy | 2 (8) | 1 (4) | 0.55 |
| Mild traumatic brain injury, n (%) | 7 (28) | 5 (20) | 0.51 |
| Psychiatric History, n (%) | |||
| Suicide attempt(s) | 6 (24) | 6 (24) | 1.00 |
| Inpatient hospitalization(s) | 13 (52) | 15 (64) | 0.57 |
| DAR (mean, SD) | |||
| Baseline | 11.5 (6.3) | 14.1 (5.6) | 0.13 |
| Midpoint double blind | 9.1 (6.3) | 13.2 (5.5) | 0.02 |
| Endpoint double blind | 9.4 (6.6) | 12.7 (5.9) | 0.07 |
| Midpoint open label | 8.8 (6.8) | 11.6 (6.5) | 0.14 |
| Endpoint open label | 7.8 (6.8) | 9.3 (6.5) | 0.41 |
| Follow-up | 8.2 (6.5) | 10.9 (6.9) | 0.17 |
| PSQI (mean, SD) | |||
| Baseline | 14.0 (2.9) | 13.8 (4.7) | 0.86 |
| Midpoint double blind | 11.7 (4.0) | 12.8 (4.3) | 0.34 |
| Endpoint double blind | 11.3 (3.9) | 12.6 (4.8) | 0.31 |
| Midpoint open label | 10.6 (3.7) | 12.1 (4.9) | 0.26 |
| Endpoint open label | 10.2 (3.6) | 11.1 (5.1) | 0.54 |
| Follow-up | 9.5 (3.3) | 10.2 (4.8) | 0.58 |
Abbreviations: SD, Standard deviation; PTSD, posttraumatic stress disorder; CAPS-5, Clinician Administered PTSD Scale for DSM-5; PCL-5, PTSD Checklist for DSM-5. DAR, Dimensions of Anger Reactions scale; PSQI, Pittsburgh Sleep Quality Index.
a
p values represent between group contrast at baseline
b
Total < 100% due to participant non-response
c
Score of ≥ 14 on the 30-Item Inventory of Depressive Symptomology, Self-Report (IDS-SR)
d
p values represent independent samples t-test between groups.