TABLE 1.
Characteristics of 20 immunocompromised patients infected with a Lactobacillus
| Strain no.a | Age (yr)/ sexb | Underlying conditionc | Anti-mitotic drug | Duration (wk) of granulo-cytopenia | Other sign(s) | Antibiotic(s) administered
|
Origin of isolates (no. of samples) | Time of death (days) after isolation of Lacto-bacillus | |
|---|---|---|---|---|---|---|---|---|---|
| Glyco-peptide | Othersd | ||||||||
| 1132 | 35/M | Lymphoma, HBMT | 8 | GVHe | IMP, PEF, MTR | Stools | |||
| 1199 | 12/M | AA | 150 | + | CAZ, CIP | Blood (4), catheter, throat | 7 | ||
| 1200 | 50/F | AML | + | 4 | Diarrhea | + | CAZ, CIP, RIF, POL (p.o.f) | Stools | |
| 1201 | 55/M | PCM, ABMT | Diarrhea | Sputum | |||||
| 1202 | 11/F | AA, CBT | 2 | + | PIP, AM, OFL (p.o.) | Blood (14), CSF | |||
| 1273 | 7/M | AML, ABMT | 2 | + | CAZ, AMX, CIP, POL (p.o.) | Blood (4; relapsed) | |||
| 1274 | 24/M | AML | + | 4 | + | CAZ, OFLO, AM, POL (p.o.) | Throat | ||
| 1284 | 4/F | ALL | + | 2 | + (p.o.) | AM, FOS | Stools | ||
| 1285 | 9/M | Relasped AML | + | 1 | + | CAZ, AM, TMP-SMZ | Blood (1) | ||
| 1286 | 35/F | AML | + | 1 | Diarrhea | CAZ, NET | Stools | ||
| 1287 | 65/M | Gut carcinoma, surgery | <1 | Septic shock | CTX, AM, MTR | Blood (1) | 1 | ||
| 1288 | 16/M | Relapsed ALL | + | 2 | Mucositis | + (po) | CAZ, NET, POL (p.o.) | Blood (2) | |
| 1290 | 29/M | Kidney transplantation | 8 | Hepatitis, diarrhea | + (po) | CAZ, TMP-SMZ, CIP | Blood (2) | 1 | |
| 1292 | 6/M | AL, CBT | 2 | GVH, diarrhea | + (po) | IMP, MTR (p.o.), TMP-SMZ | Stools | ||
| 1293 | 2/F | AML, HBMT | 3 | GVH, mucositis | + | CAZ, AM, POL (p.o.) | Blood (5) | ||
| 1294 | 80/M | Diabetes, liver failure | Blood (1) | ||||||
| 1295 | 34/M | AIDS | 8 | TMP-SMZ | Blood (1) | ||||
| 1296 | 10/M | AML | + | 1 | + | CAZ, AM | Blood (1) | ||
| 1297 | 52/M | PCM, ABMT | 8 | Septic shock | + | PIP, CIP, GM | Lower respiratory tract | ||
| 1298 | 29/M | AIDS | 1 | Shock, diarrhea | TMP-SMZ | Blood (3) | 1 | ||
a
All strains except strains 1294 and 1295 were L. rhamnosus.
b
M, male; F, female.
c
AA, aplastic aplasia; ABMT, autologous bone marrow transplantation; AL, acute leukemia (ALL, lymphoblastic; AML, myeloid); HBMT, homologous bone marrow transplantation; CBT, cord blood transplantation; PCM, plasma cell myeloma.
d
AM, amikacin; AMX, amoxicillin; CAZ, ceftazidime; CIP, ciprofloxacin; CTX, cefotaxime; FOS, fosfomycin; GM, gentamicin; IMP, imipenem; MTR, metronidazole; NET, netilmicin; OFL, ofloxacin; PEF, pefloxacin; PIP, piperacillin; POL, polymyxin B; RIF, rifampin; TMP-SMZ, trimethoprim-sulfamethoxazole.
e
GVH, graft-versus-host disease.
f
p.o., per os.