TABLE 1.
Characteristics of the included trials comparing BSM to no filling material (NoBSM)
| Author (year) | Country (setting) | M:F ratio | Mean age in years ± SD or (range) | Longest follow‐up in months (reference) | Sample size (patients randomized) | Number of implants | Maxilla or Mandible (anterior or posterior) | Intervention | Co‐intervention | Control | Outcomes used in the meta‐analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intervention | Control | Intervention | Control | Intervention | Control | Intervention | Control | ||||||||
| Bittner et al.30 | USA (educational) | 9:23 | 52.3 ± 4 | 12 (placement) | 16 | 16 | 16 | 16 | maxilla (anterior) | Xenograft (Bio‐oss collagen) | None | None | Mid‐buccal mucosal recession | ||
| Chen et al.31 | Australia (private practice) | 15:12 | 14:21 | 41.15 ± 1.2 | 42.36 ± 0.72 | 24 (loading) | 27a | 35a | 27a | 35a | maxilla (anterior) | Autograft | Resorbable membrane (Resolut) | Resorbable membrane (Resolut) | Implant failure |
| Non‐resorbable membrane (Gore‐tex) | |||||||||||||||
| Connective‐tissue graft | Connective‐tissue graft | Complications | |||||||||||||
| Chen et al.32 | Australia (private practice) | 7:13 | 3:7 | 46.8 ± 10.8 | 43.2 ± 10.8 | 36 (loading) | 20a | 10 | 20a | 10 | maxilla (anterior) | Xenograft (Bio‐oss) | Collagen membrane (BioGuide) | None | Complications |
| Vertical buccal bone resorption | |||||||||||||||
| Horizontal buccal bone resorption | |||||||||||||||
| Cornelini et al.33 | Italy (educational) | 9:11 | 45 years (21–61) | 6 (placement) | 10 | 10 | 10 | 10 | Both (anterior) | Xenograft (Bio‐oss) | Collagen membrane (BioGuide) | Collagen membrane (BioGuide) | Vertical interproximal bone resorption | ||
| Daif34 | Egypt (educational) | 10:18 | 34 (22–48) | 6 (loading) | 14 | 14 | 14 | 14 | mandible (anterior) | Alloplast (ß‐TCP) | None | None | N/A | ||
| Angelis35 | Italy (private practice) | 21:19 | 21:19 | 46.4 (20–77) | 47.7 (24–75) | 12 (loading) | 40 | 40 | 40 | 40 | Both (Both) | Xenograft (Endobon) | Collagen membrane (OsseoGuard) | Collagen membrane (OsseoGuard) | Soft‐tissue esthetics |
| Implant failure | |||||||||||||||
| Complications | |||||||||||||||
| Vertical interproximal bone resorption | |||||||||||||||
| Gher et al.36 | USA (educational) | 15:5 | 14:6 | 58 (26–80) | 53.95 (27–81) | 6 (placement) | 20 | 20 | 22 | 21 | Both (Both) | Allograft (DFDBA [Calcitek]) | Non‐resorbable membrane (Gore‐tex) | Non‐resorbable membrane (Gore‐tex) | Vertical buccal bone resorption |
| Girlanda et al.37 | Brazil (educational) | 4:18 | (21–58) | 6 (placement) | 11 | 11 | 11 | 11 | Maxilla (anterior) | Xenograft (Bio‐oss collagen) | None | None | Mid‐buccal mucosal recession | ||
| Grassi et al.38 | Italy (educational) | 6:9 | 6:8 | 47.3 ± 8.7 | 42.6 ± 10.7 | 6 (placement) | 15 | 14 | 15 | 14 | Maxilla (anterior) | Xenograft (Bio‐gen) | None | None | Vertical buccal bone resorption |
| Horizontal buccal bone resorption | |||||||||||||||
| Jacobs et al.39 | USA (educational) | 8:11 | 6:8 | 53 ± 20 | 65 ± 14 | 10 (placement) | 19 | 14 | 19 | 14 | Maxilla (anterior) | Xenograft (Bio‐oss) | Collagen dressing (Collagen plug) | None | Soft‐tissue esthetics |
| Vertical buccal bone resorption | |||||||||||||||
| Horizontal buccal bone resorption | |||||||||||||||
| Mid‐buccal mucosal recession | |||||||||||||||
| Mastrangelo et al.40 | Italy (private practice) | 31:20 | 32:19 | 44 ± 6.7 | 36 (loading) | 51 | 51 | 64 | 51 | Maxilla (anterior) | Xenograft (Bio‐oss) | Collagen membrane (Ostebiol) | None | Soft‐tissue esthetics | |
| Implant failure | |||||||||||||||
| Vertical interproximal bone resorption | |||||||||||||||
| Mohamed et al.41 | Egypt (educational) | 2:8 | 2:3 | 33 ± 5 | 35 ± 11 | 6 (placement) | 10a | 5 | 14a | 7 | maxilla (anterior) | Allograft (Puros) | None | None | Vertical buccal bone resorption |
| Alloplast (Bio‐resorp) | |||||||||||||||
| Paknejad et al.42 | Iran (educational) | 3:17 | 38.8 (37–57) | 4–6 (placement) | 20 | 14 | 13 | maxilla (anterior) | Xenograft (Compact bone) | None | None | Vertical buccal bone resorption | |||
| Prosper et al.43 | Italy (educational) | 39:44 | 46.2 ± 14.3 | 48 (placement) | 83 | 56 | 55 | Both (posterior) | Alloplast (Biosite) | None | Resorbable membrane (Osseoquest) | Implant failure | |||
| Sanz et al.44 | Italy | 22:21 | 19:24 | ? | 4 (placement) | 45b | 46b | 43 | 43 | Maxilla (anterior) | Xenograft (Bio‐oss collagen) | None | None | Implant failure | |
| Spain | Vertical buccal bone resorption | ||||||||||||||
| UK | |||||||||||||||
| (educational) | Horizontal buccal bone resorption | ||||||||||||||
| Spinato et al.45 | Italy (private practice) | 11:30 | 42.5 (22–70) | 32 (placement) | 41 | 22 | 23 | Maxilla (anterior) | Xenograft | None | None | Complications | |||
| Allograft | Vertical interproximal bone resorption | ||||||||||||||
| Autograft | |||||||||||||||
| Combination | mid‐buccal mucosal recession | ||||||||||||||
| Yuenyongorarn et al.46 | USA (educational) | 4:6 | 2:8 | 65.4 (41–83) | 12 (placement) | 10 | 10 | 10 | 10 | Maxilla (anterior) | Xenograft (Bio‐oss) | None | None | Implant failure | |
| Vertical interproximal bone resorption | |||||||||||||||
| mid‐buccal mucosal recession | |||||||||||||||
a
Combined groups.
b
One patient had a failure and four lost to the follow up.
? = not mentioned.