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. 2021 Jun 19;61(9):1182–1194. doi: 10.1002/jcph.1865

Figure 4.

Figure 4

Probability of target attainment (top) and probability of imipenem trough > 5 mg/L (bottom) comparing normal renal function (NRF)—CrCl of 100‐130 mL/min—with augmented renal clearance (ARC)—CrCl of 150‐250 mL/min—in a 70‐kg critically ill patient with varying degrees of total burn surface area (TBSA). Each group is simulated with n = 1000 replicates with setting albumin of 3.45‐4 g/dL corresponding to TBSA of 0%‐10%, setting albumin of 2.6‐3.15 g/dL corresponding to a TBSA of 25%‐50%, and setting albumin of 1.5‐2.2 g/dL corresponding to a TBSA of 70%‐100%.