Table 3.
Comparison of Final Model‐Predicted Mean Pharmacokinetic Parameters With Literature‐Reported Mean Pharmacokinetic Parameters in Healthy, Renally Impaired, and Burn Populations
| Population | Conditions | Final Model‐Predicted Mean Parameters | Mean Parameters Observed in Literature | Citation |
|---|---|---|---|---|
| Healthy |
Albumin, 4 g/dL; weight, 76 kg; CrCl, 106 mL/min |
Vc, 16.89 L; Vp, 9.7 L; Cl, 12.1 L/h |
Vc, 9.37‐15.83 L; Vp, 5.84‐6.41 L; Cl, 11.5‐12.53 L/h |
Bhagunde et al, 2019; Coen van Hasselt et al, 2015 |
| Renal impairment |
Albumin, 4 g/dL; Weight, 58 kg; CrCl, 54.1 mL/min |
Vc, 13.14 L; Vp, 9.7 L; Cl, 8.19 L/h |
Vc, 11.4 L; Vp, 3.56 L Cl, 7.95 L/h |
Yoshizawa K et al, 2012 |
| Burn |
Albumin, 3 g/dL (corresponds to TBSA 32.26%); weight, 70.8 kg; CrCl, 126.3 mL/min |
Vtot, 50.43 L; Vc, 22.45 L; Vp, 27.98 L; Cl, 12.81 L/h |
Vtot, 15.69‐97.7 L; Vc, 28.28 L; Vp, 41.23 L; Cl, 11.1‐17.8 L/h |
Daily et al, 2003 (weight, 75.2 kg; TBSA, 27.6%; CrCl, 143 mL/min) Gomez et al, 2015 (weight, 68 kg; TBSA, 36.3%) Boucher et al, 1990 (weight, 71.3 kg; TBSA, 43.4%; CrCl, 109.6) Boucher et al, 2016 (weight, 90 kg; TBSA, 23%; all patients with CVVH) Machado et al, 2017 (weight, 67.5 kg; TBSA, 31%; CrCl not reported) Li et al, 2019 (burn data borrowed from Boucher et al, 2016) |